Antiangina drugs are medicines that relieve the symptoms of angina pectoris (severe chest pain). Purpose The dull, tight chest pain of angina occurs when the heart’s muscular wall is not getting enough oxygen.
By relaxing the blood vessels, antiangina drugs reduce the heart’s work load and increase the amount of oxygenrich blood that reaches the heart. These drugs come in different forms, and are used in three main ways:
• taken regularly over a long period, they reduce the number of angina attacks.
• taken just before some activity that usually brings on an attack, such as climbing stairs, they prevent attacks.
• taken when an attack begins, they relieve the pain and pressure.
Not every form of antiangina drug can be used in every way. Some work too slowly to prevent attacks that are about to begin or to relieve attacks that have already started. These forms can be used only to reduce the number of attacks. Be sure to understand how and when to use the type of antiangina drug that has been prescribed.
Description
Antiangina drugs, also known as nitrates, come in many different forms: tablets and capsules that are swallowed; tablets that are held under the tongue, inside the lip, or in the cheek until they dissolve; stick-on patches; ointment; and in-the-mouth sprays.
Commonly used antiangina drugs include isosorbide dinitrate (Isordil, Sorbitrate, and other brands) and nitroglycerin (Nitro- Bid, Nitro-Dur, Nitrolingual Spray, Nitrostat Tablets, Transderm-Nitro, and other brands). These medicines are available only with a physician’s prescription. Recommended dosage The recommended dosage depends on the type and form of antiangina drug and may be different for different patients. Check with the physician who prescribed the drug or the pharmacist who filled the prescription for the correct dosage. Always take antiangina drugs exactly as directed. The medicine will not work if it is not taken correctly.
Some Antiangina Drugs
Calan (calan SR, isoptin, isoptin SR, verelan)
Cardene (nicardipine hydrochloride)
Cardizem (diltiazem hydrochloride)
Imdur, Ismo, Monoket (isosorbide mononitrate)
Remember that some forms of antiangina drugs work too slowly to relieve attacks that have already started. Check with the physician who prescribed the medicine for instructions on how to use the type that has been prescribed. Patients who are using slower-acting forms to make attacks less frequent may want to ask their physicians to prescribe a fast-acting type to relieve attacks. Another method of treating the frequency of attacks is to increase the dosage of the long-acting antiangina drug.
Do this only with the approval of a physician. These medicines make some people feel lightheaded, dizzy, or faint when they get up after sitting or lying down. To lessen the problem, get up gradually and hold onto something for support if possible. Antiangina drugs may also cause dizziness, lightheadedness, or fainting in hot weather or when people stand for a long time or exercise. Use caution in all these situations. Drinking alcohol while taking antiangina drugs may cause the same problems. Anyone who takes this medicine should limit the amount of alcohol consumed.
Before using antiangina drugs, people with any of these medical problems should make sure their physicians are aware of their conditions:
• recent heart attack or stroke • kidney disease • liver disease • severe anemia • overactive thyroid • glaucoma • recent head injury
Side effects A common side effect is a headache just after taking a dose of the medicine. These headaches usually become less noticeable as the body adjusts to the drug. Check with a physician if they are severe or they continue even after taking the medicine for a few weeks.
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