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Karen finds herself seduced by the glamorous life of new BFF Rebecca Duvall -- but can Rebecca be trusted? What will Karen's ascent mean to her relationship with Dev? And will Rebecca drive Derek insane? Eileen introduces new beau Nick to ex-husband Jerry, while Julia panics when her son Leo goes missing.
As the girls inch closer to final team selections, they must first pass the semi-qualifications. But that is easier said than done as they each face problems: Kelly must deal with her mom (special guest star Kathy Najimy) being in town and out for Kaylie's blood, Lauren stresses over Payson constantly watching her about her health, and there's a mole in the group, trying to sabotage the team. Meanwhile, Coach Mac's mandatory curfew puts a kink in Payson's love life.
After a wild night of partying, Wade wakes up with a massive hangover, an uninvited houseguest and no memory of what happened the night before. Meanwhile, George takes an unplanned roadtrip to New Orleans, and Lemon finally confesses her troubles to her father, Brick.
House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams, and Dominika discovers a secret that could ruin her relationship with House.
Blair feels like her Upper East Side status might be slipping away and devises a plan to assure that doesn't happen. Meanwhile, Lily throws a family gathering - including William, Carol and Lola - in an attempt to prove the van der Woodsen family is as united as ever. Finally, Nate digs into Diana's past and is surprised by what he discovers.
The corpse of a truck company employee is found in the middle of the woods. After the victim's son is questioned, Booth and Brennan visit his karate class in search of a motive. Back at the lab, Hodgins is going overboard purchasing lab equipment. Then, Booth's son Parker returns from England and Brennan is apprehensive about how he'll react to his new baby sister.