jenny cares 

News item C2NN by Annelies

BOSTON, Dec. 31, 2008 (Reuters)
Merck's popular osteoporosis drug Fosamax and other similar drugs may carry a risk for esophageal cancer, a FDA official said on Wednesday.
  Diane Wysowski of the FDA's division of drug risk said researchers should check into potential links between so called bisphosphonate drugs and cancer.
  In a letter in Thursday's New England Journal of Medicine, Wysowski said since the initial marketing of Fosamax, known generically as alendronate, in 1995, the FDA has received 23 reports in which patients developed esophageal tumors. Typically, two years lapsed between the start of the drug and the development of esophageal cancer. Eight patients died, she reported.
  In Europe and Japan, 21 cases involving Fosamax have been logged, with another six instances where Procter & Gamble's Actonel or risedronate and Didronel or etidronate, and Roche's Boniva (ibandronate) may have been involved. Six of those people died.
  Esophagitis, which is an inflammation of the lining of the tube carrying food to the stomach, is already know to be a side effect of the drugs, which is why patients are instructed to remain upright for at least a half hour after taking them. In addition, Wysowski said, doctors should avoid prescribing the drugs to people with Barrett's esophagus, which is a change in the lining that leads to the stomach. It is often found in people with acid reflux disease and itself increases the risk of cancer.

  (These drugs... Fosamax etc) aim to treat bone-weakening osteoporosis by increasing bone mass. An estimated 10 million Americans, mostly women, have osteoporosis. http://www.newsdaily.com/stories/tre4bu4tx-us-osteoporosis-cancer/