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Aug 20, 2010

FIBROMYALGIA and HFCS (High Fructose Corn Syrup)
Janice Lorigan wrote "High Fructose Corn Syrup and the Fibromyalgia Connection" - a book that's fairly easy to read;. Not too many big words I made some notes as I was reading which I'll share with you here.


  • Consume food or drink products that contain HFCS, corn syrup*, crystalline fructose, or corn syrup solids.
  • Inhale wet fingernail polish fumes.
  • Inhale pesticides, insecticides, fumigants, or malathion.
  • Drink liquids which contain more than 5% pesticides.
  • Eat rice**

*Old-fashioned corn syrup does not disturb metabolic processes for most people. However, many manufacturers are still using the terms high fructose corn syrup and corn syrup interchangeably.
**Rice- Unfortunately, rice absorbs arsenic from the soil. (Soil of many agricultural areas of US and o' countries has elevated levels of arsenic. Even organic rice may contain an excessive amount of arsenic if grown where cotton grew previously.)

  • Read ingredients levels on food and beverage containers.
  • Be cautious when eating out.
  • Stock your pantry with organic biscuits and cereals.
  • Stock your fridge with fresh fruits and vegetables.
  • Wash fruits and vegetables thoroughly.
  • When possible, drink filtered water.
  • Choose organic milk, juice, and wine.
  • Eat a balanced diet (without HFCS!)

METABOLISM - Non-fibromyalgic consumers seem to metabolize HFCS with no noticeable unpleasant effects. BUT fibromyalgics experience negative effects after eating or drinking HFCS. However, the effects aren't immediate so it makes it difficult to make the connection between the pain and the HFCS.
THE TROJAN HORSE: the journey of the HFCS into the body is like the Trojan Horse fable. HFCS tastes like food and digests like food in the stomach. But as metabolism begins the body discovers the deception. Part of the HFCS is toxic to fibromyalgics, i.e. the chemically manipulated fructose that used to be glucose.
The manipulated fructose part of HFCS confuses the metabolic processes and exhausts the intestines and liver because this fructose is unstable. ORGANS and NEUROTRANSMITTERS are affected.
SEROTONIN and DOPAMINE are neurotransmitters that contribute to feelings of contentment and well-being. During pain the dopamine levels in fibromyalgics are significantly lower than dop' levels in non-fibromyalgics.
Serotonin - 95% of serotonin is produced in the intestines. In fibromyalgics the low levels of serotonin contribute to depression and catastrophic or negative thinking. As long as the intestines are overtaxed with the abnormal glucose/fructose metabolism problem, serotonin production may be v low.
ENZYMES - influence the speed of metabolism and play powerful roles in the metabolic process. One of the important roles of the enzyme is to remove toxins from the body.... but a high level of toxins suppresses the production of enzymes, so the intestines are burdened.
There is a connection between fibromyalgia and fascia.
WHAT IS FASCIA? - a stretchy web existing all over the body, lying just below the skin. Fascia surrounds everything: organs, brain, toes, fingers, limbs, neck, muscles. It helps to hold the body together. It supports and separates organs and muscles.
Impaired fascia of the fibromyalgic becomes tighter and more immobile, especially in the neck, upper back, shoulders, lower back.
At times the fascia of fibromyalgics contains and restrains the muscle, ligaments, tendons too tightly. Manipulation of the fascia with massage, acupuncture or acupressure can provide some comfort.
HOW DOES THE FASCIA BECOME IMPAIRED? Janice Lorigan's theory is that the strange enzymes from HFCS aren't wanted by the body so it attempts to excrete them via the skin pores. While passing through the fascia on the way to the skin, an adverse chemical reaction results, stiffening the fascia until the HFCS enzymes are expelled from the fascia. During that process the fibromyalgic feels pain and achiness and requires additional sleep time to recover.
WHY MORE SLEEP? because the intestines, liver, endocrine system, and cells have to work v hard to rid the body of the HFCS chemicals, thus causing FATIGUE.
THALAMUS -part of the Central Nervous System -an area of the brain -made up of neurons - plays a part in PAIN PROCESSING.

May 3, 2010


 -- CFS/CFIDS Awareness Day & Fibromyalgia Awareness Day
 12th May
-- National (U.S.) Mental Health Month visit the Mental Health America site for information: "Live Your Life Well"
-- May is Lupus Awareness Month - Learn about Lupus -Lupus Foundation of America site: | | 
-- 9-17 May is European Congenital Heart Awareness Week
-- Psych Week : Awareness for Mental Disorders
-- May is Better Sleep Month - Get some sleep tips at The Better Sleep Council:
-- May is American Stroke Month: ...Every Minute Matters! Heart Attack Warning Signs 
Stroke Warning Signs Cardiac Arrest Warning Signs
-- May is National High Blood Pressure Education Month U.S.
National High Blood Pressure Education Program 
National Heart Lung & Blood Institute: Heart and Vascular Diseases Lung Diseases Blood Diseases Educational Materials 
-- BloodPressure Awareness Find out if you are at risk.
-- May is Better Hearing & Speech Month - The Communication Health of an Aging America:  
Warning signs of speech, language, and hearing problems
-- Water Safety Month: To learn how you can protect children from drowning, go to  
  Most of the above came from 

Mar 24, 2010

That old bugbear, fibromyalgia

Lately I dropped in to Textbook of Pain to see what it had to say about fibromyalgia, or as it is commonly referred to, FM. I found out quite a lot I never knew before, actually.
I already knew that people who are diagnosed with FM hurt - the main complaint is body pain. Careful differential diagnosis comes first; serious major depressions, panic and anxiety disorders are ruled out.
Next, apparently there is more than one kind of FM, primary and secondary. They look and act a lot alike so clinical reasoning is key: Existence of a prior condition means the FM must be treated as secondary:
   1. Rheumatoid arthritis - 30%
       of patients will also likely have FM
   2. Systemic Lupus Erythematosus - 40%
   3. Sjögren's Syndrome - 50%

What "secondary" means, is that patients will have two kinds of pain at once, and treatment of the primary condition must be managed in a way that won't aggravate the pain from the secondary FM. Furthermore, one kind of pain might be well-managed and the other not. For example, "increasing the dosage of antirheumatic medications in the absence of active inflammation may have little effect on the pain amplified by FMS." There are issues with steroid treatment - e.g., patients withdrawing from steroid treatment for their RA might find the FM pain increasing temporarily with each decrease in glucocorticoid dosage. This is a surprise in that primary FM has not been helped with glucocorticoid.
Various infectious and inflammatory conditions such as Hep C, TB, syphilis, and Lyme disease, are associated with FM. FM, and aches and pains from subacute bacterial endocarditis could be confused with it.

Primary FM is referred to these days as a "disorder of abnormal sensory processing of sensory information within the CNS, exhibiting a limited array of recognized objective physiological and biological abnormalities."
1. Mountz et al 1995: CT scans showed abnormally low regional cerebral blood flow in thalamic nuclei and other pain processing brain structures, correlated with spinal fluid substance P levels.
2. Gracely et al. 2002: fMRI evidence for augmented pain processing in brain
3. abnormal spinal cord "wind-up"
4. In over 60% of cases, there exists a temporal relationship to a physical trauma or febrile illness and FM onset.
5. Evidence relating FM to actual muscle abnormality or pathology is weak, scant, inconclusive, or completely missing, in both invasive and non-invasive testing compared to healthy controls. At a neurochemical level, findings support the concept of objective pain amplification. Various pro-nociceptive substances, and a few anti-nociceptive substances, have been examined. One of the pro-nociceptive substances is  substance P  (P for pain):
1. Russell 1998: Elevated levels of Substance P found in cerebral spinal fluid of patients diagnosed with FM
2. Vaeroy et al 1988, Russell 1998, Mountz et al 1995: average concentrations of  substance P  in CSF found to be 2 to 3-fold higher in FM than in healthy controls. Substance P levels in saliva, serum or urine were not elevated.
3. Cerebral spinal fluid contains an esterase for breaking down Substance P - this substance was normal, not deficient, so the elevated levels of substance P must be because the body makes more than the esterase can take care of.
4. substance P  is elevated in other conditions such as rheumatic diseases with or without FM (Russell, unpublished).
5. In painful OA of the hip, levels of Substance P returned to normal after hip replacement.
6. Tsigos et al 1993, Sjostrom 1988: In chronic low back pain, and diabetic neuropathy, cerebral spinal fluid Substance P levels are lower than normal. (So go figure...)
Another substance is  nerve growth factor, elevated in CSF of those who have primary but not secondary FM (Giovengo et al 1999). It may even be NGF that is responsible for elevated levels of Substance P, whereas in secondary FM, the primary condition (arthritis etc.) itself may be responsible. Cytokines called interleukins were found to be elevated, specifically IL-8 and IL-6. IL-8 is stimulated by Substance P. G-protein-coupled receptors were found to not be able to inhibit intracellular cyclic AMP production by adenylate cyclase - more cyclic AMP was found floating around. This is being considered as a cause of the allodynia characteristic of FM. Apparently there is no opioid deficiency; levels of Dynorphin A are found to be normal. Serotonin levels, however, are lower.
Numbers of active FM tender points correlated nicely with concentrations of serotonin in body serum (Wolfe et al 1997b). Noradrenaline levels might be low; concentration of methoxyhydroxyphenylglycol, the inactive metabolite of noradrenaline, was found to be significantly lower than normal in FMS cerebrospinal fluid (Russell et al 1992).
Up to 35% of patients with FM, when tested using hypoglycemic hyperinsulinaemic clamp procedures, show inadequate responsiveness, or excessive response to feedback inhibition, of the hypothalamic-pituitary portion of the HPA axis (Adler et al 1999). This shows exaggerated adrenocorticotropic hormone response to insulin-induced hypoglycemia or stressful exercise and indicates poor tolerance for physiological stress.
Women are more commonly affected than men, and FM onset is often perimenopausal. About 30% of female FM patients are prematurely menopausal due to surgical removal of female reproductive organs. Forty-four % of female FM patients have premenstrual syndrome and pain which cycles in phase with their menstrual cycle (Anderberg et al 1998). It is thought that these differences are less a feature of estrogen and more to do with serotonin (Nishizawa et al 1997).
Sleep is a problem in FM.
Deep stage IV non-REM sleep is when human growth hormone is released. It stimulates the liver to produce a long half-life peptide called insulin-like growth factor-1, found to be deficient in FM (Bennett et al 1997). It has been hard to develop a treatment based on administering this, even though it helps; growth hormone therapy is expensive at $1000/month. Iyengar et al 2005: in a study of 80 multi-case families, 8 genetic markers were detected. Posted by Diane Jacobs

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Posted: Mar 24, 2010 4:13pm


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Jenny Dooley
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