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Jul 22, 2013

I have recently become a Kindness Ambassador for Life Vest Inside! 

They are an amazing non-profit organization dedicated to spreading kindness, empowering people and building self-esteem and self-value. 

Their motto is simple: help people recognize the AMAZING potential they have to effect real and positive change in the world through simple yet powerful acts of kindness! 

You may be familiar with their viral video, Kindness Boomerang! Bottom line, they are committed to changing the world in a big way. 

They are launching a global crowdfunding campaign through Indiegogo on Sunday, July 21st and aiming to raise funds to bring the organization to the next level. 
 

With Kindness, I humbly Thank You! 

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Posted: Jul 22, 2013 10:05pm
Jun 18, 2013

Dear Caring members of this fine site, PLEASE don't feel discouraged when things don't go well at first. It will in time, we ALL just need patience!

If everything was easy without challenges or hurdles, nothing would be advancing on this planet.  After all, there can be no Light without Darkness and we here are Light-bringers.

We just need to persevere, look in front of us, take another step and NEVER look back (the past is gone, we must live in the now to bring forth the future). 

So THANKS AGAIN Friends for your commitment to help and share!

Looking @ the comment section on Care2, I have noticed that many people either don't have FB or find it evil!

Just remember that no tools (and that includes websites) are evil per se, it is only some of the people using it that are, it is NOT better or worse than other tools ( Television, Telephone, Letters, Protests, etc ) as all of these can be used to insult or compliment, peace or violence!

My take on it is to use them for good so as to strive for balance in this world!

If you still won't OR can't use FB, you could use Google+, Twitter or Pinterest! I have used all of these today to send ripples out there!

If anyone wants to use these tools and need help, I would be happy to lend a hand (but you must be patient as I am only one!).

Here hoping you feel good @ the moment (whatever the moment is)! 

Be at Peace and Smile, it's worth it!

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Posted: Jun 18, 2013 1:26pm
Feb 27, 2013
Let us place the elderly in prisons

They will be entitled to a shower a day, video surveillance in case of problems. Three meals a day, use of a computer, a TV with cable or satellite. Access to the library and gym.


Put criminals in nursing homes

They will have cold meals with the lights off at 20:00, a bath a week, live in a smaller room and pay $2000.00 per month!


That is justice now, this message must be heard!

Share if you agree with that!
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Posted: Feb 27, 2013 4:05pm
Jan 3, 2013

Open your eyes ... You will see wonderful things !!!

Open your ears ... You will hear wonderful things !!!

Open your heart ... You will feel wonderful things !!!

Open your mind and You will remember it all !!!

Paul Girardin
January 2013

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Posted: Jan 3, 2013 8:46pm
Dec 20, 2012

This is exactly what has been on my heart and mind in the last few days.

The holidays are upon us and it can be a very joyful time of year.

Some of us have problems during the holidays and sometimes are overcome with great sadness when we think of or remember the loved ones who are no longer with us or too far.

And, many people have no one to spend these times with and are besieged by loneliness.

We all need caring and loving right now.

I ask my Care2 friends (and other good souls reading) wherever you might be, to share your thoughts here or on any other medium (like Facebook) to give a moment of support to all those who have family problems, health struggles, job issues, worries of any kind and just need to know that someone cares.

Do it for all, for nobody is immune.

I hope to see this posted on as many places as possible (by friends and strangers alike) just for moral support.

I received this from a friend elsewhere, added some of my own musings and posted it here and there, and I hope you also do the same.

I wish you a very Merry (whatever you celebrate) from my household to yours!

Also, if all of you can do just ONE kindness for another person (family, friend or complete stranger) in this holiday period (whatever holiday you celebrate), the world will at least vibrate a little more positively this year's end!

Think what just a coffee, a soup & a donut could do for a freezing starving lonely person and you will get the true meaning of the Holidays.

If you can do better than that, more power to you!

Thank you

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Posted: Dec 20, 2012 2:29am
Nov 21, 2006


DID YOU KNOW?

Tigers can run as fast as 35 miles an hour and they're among the most powerful hunters on land or in water.
There were once 100,000 wild tigers ranging from Siberia to India, but today there are only an estimated 5,000 remaining.


Watch the videos and learn more !

Here is the link : http://60minutes.yahoo.com/segment/19/tigers


It's in those moments that I wish I had a magic wand to undo all this nonsense !!! 
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Posted: Nov 21, 2006 8:56pm
Nov 19, 2006
Photo : The shell of the sea-dwelling cone snail Conus regius, which uses its venom to kill worms so it can capture and eat them. A toxin from Conus regius venom helped University of Utah researchers identify an entirely new way to treat severe pain caused by injury to the nervous system. (Credit: Kerry Matz)

A brand new approach to treating severe nerve pain -- by aiming drugs at a previously unrecognized molecular target -- has been discovered by University of Utah scientists who study the venoms of deadly, sea-dwelling cone snails.


"We found a new way to treat a chronic and debilitating form of pain suffered by hundreds of millions of people on Earth," says J. Michael McIntosh, a University of Utah research professor of biology, and research director and professor in the Department of Psychiatry. "It is a previously unrecognized mechanism for treating pain."

The findings are being published the week of Nov. 13 in the online edition of the journal Proceedings of the National Academy of Sciences.


The study in rats found that cone snail toxins named RgIA and Vc1.1 can treat nerve hypersensitivity and pain by blocking a molecule in cells known as the "alpha9alpha10 nicotinic acetylcholine receptor."


"The numerous analgesic compounds currently available are largely ineffective" for chronic nerve pain, McIntosh and colleagues write. "Our findings not only suggest a previously unrecognized molecular mechanism for the treatment of neuropathic pain, but also demonstrate the involvement of alpha9alpha10 nicotinic receptors" in nerve injury.

McIntosh emphasized neither substance will be on the market soon. Vc1.1, also known as ACV1, is being developed by an Australian company, Metabolic, and is undergoing trials of its effectiveness in human patients. While Metabolic has said the drug targets nicotinic receptors, McIntosh says alpha9alpha10 nicotinic receptors have not been reported previously as a target for any kind of painkilling medication. McIntosh says Vc1.1 is administered by subcutaneous (under the skin) injection.


McIntosh hopes the new findings make it feasible to develop a painkiller based on RgIA that could be taken orally, but he believes that will take at least 10 years.

McIntosh co-authored the study with two colleagues in the University of Utah Center for Neuropeptide Pharmacology -- Baldomero "Toto" Olivera, a distinguished professor of biology, and Michael Ellison, a postdoctoral fellow in biology -- and with Michelle Vincler, Shannon Wittenauer and Renee Parker at the Wake Forest University School of Medicine in Winston-Salem, N.C.


The research was funded by the National Institutes of Health.




A Pain in the Nerves


The study dealt with what is known as neuropathic pain, which is chronic pain due to injury to the nerves, spinal cord or brain.


Such pain can result from diabetes damage to nerves in the feet or elsewhere, spinal injury, degenerative disc disease, alcoholism, failed low-back surgery, tumors compressing nerves, spinal tumors, repetitive motion disorders, multiple sclerosis, infection, stroke, traumatic brain injury, shingles, nerve toxins and electrical or other damage to peripheral nerves. Sometimes, doctors are unable to find a cause.


Symptoms can include numbness and pain that feels like constant burning, "pins and needles," sharp shooting pain, electricity or electrical shock, or tingling. People with neuropathic pain often are hypersensitive to previously innocuous stimuli -- for example, feeling pain from a foot rubbing against the inside of a shoe -- and feel an exaggerated response to things that are painful.


Common pain medicines like aspirin, ibuprofen and acetaminophen often fail to relieve neuropathic pain. Morphine-like opiods such as oxycodone sometimes are used, but can cause constipation, nausea and a spaced-out feeling.
 

Anticonvulsant drugs for epilepsy sometime are used to reduce the pain by decreasing nerve cell excitability, but have side effects such as lethargy, fatigue, clouding of mental state and weight gain, McIntosh says. Antidepressants and muscle relaxants have been used, but they can cause weight gain, nausea and sexual dysfunction.


Topical treatments include capsicum cream derived from chili peppers, but they usually are not very effective.


"There really is no highly effective treatment available for this kind of severe pain, so having a new way to treat it is exciting," McIntosh says. If the new discovery eventually leads to a new pain drug that is combined with existing treatments, "you may be able to reduce the pain to a lower level than ever before. No one drug is going to fully treat all pain, so having a new way is like having a backup catcher if the first catcher misses the ball."


How the Study was Performed


The toxins in the study come from two cone snail species that eat worms, unlike relatives that eat fish or snails and occasionally deliver a fatal sting to a human fisherman.


-- RgIA is from the species Conus regius, which measures 1.6 to 2.8 inches in length and lives from Georgia southward along Central America to Brazil's central coast.


-- Vc1.1 is from the species Conus victoriae, which measures 1.4 to 2.8 inches long and lives off portions of Australia.


RgIA and Vc1.1 fit like keys into lock-like alpha9alpha10 nicotinic acetylcholine receptors, which are found on nerve cells and are in the family of receptors activated by nicotine from cigarette smoking.


Alpha9alpha10 nicotinic receptors are found in a variety of body tissues, including white blood cells and the dorsal root ganglia -- a group of nerve cells near the spine and involved in pain transmission.


The new study showed alpha9alpha10 nicotinic receptors provide a previously unknown route to pain relief. McIntosh says a patent is pending on this new mechanism.


One form of severe nerve pain is known as sciatica, and occurs when a herniated disk in the lower back causes pain to one or both sciatic nerves, which extend from the lower back to the hips, buttocks and back of the thighs.


For the study, the North Carolina co-authors tied sutures loosely around one of each rat's two sciatic nerves to mimic nerve compression and injury from sciatica. That made the rats overly sensitive to touch on one hind paw but not the other. Each rat's sensitivity was assessed by measuring how much pressure could be applied to a hind paw with a blunt Teflon tip before the rat pulled away the paw.


Normal rats could withstand 4.7 times more pressure before withdrawing their paws, compared with rats with sciatica. When cone snail toxin RgIA was injected, the rats with sciatica were able to tolerate a stronger touch from the tip -- both four hours and 24 hours after the drug was given. The highest dose completely reversed the hypersensitivity caused by sciatica, with no adverse effects. Daily injections "produced a sustained analgesic effect," the researchers wrote.

RgIA was such a potent pain reliever that "about 10 billionths of an ounce reversed the hypersensitivity to pain," McIntosh says.


Vc1.1 had a similar effect -- replicating studies by other researchers -- allowing rats with sciatica to tolerate touch with greater pressure.


The new study is not McIntosh's first involving chronic pain. As an incoming college freshman working in Olivera's lab in 1979, McIntosh discovered in cone snails the natural form of a drug now used against severe nerve pain. It is Prialt, which must be injected into fluid surrounding the spinal cord as a treatment for severe pain due to cancer, AIDS, injury, failed back surgery and certain nervous system disorders.


This article can be found at this web address : http://www.sciencedaily.com/releases/2006/11/061113180457.htm

More on this subject can be found here : http://brain.utah.edu/newsroom/snails060821.html
and here : http://search.utah.edu:8765/custom/query.html?qpurl=site%3Abrain.utah.edu&qpname=Brain+Institute&qt=snail+toxin

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Posted: Nov 19, 2006 7:25pm
Feb 11, 2006

The article about the firing of a teacher really got me enraged


When a country talks about war and God in the same sentence, it's horrible enough !

But when they fire a teacher for saying the word "Peace", it's even worse !

What's next, death by firing squad for saying "I love U" in a public place ?
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Posted: Feb 11, 2006 3:21pm
Feb 6, 2006
Name: All those doing good !
Type: Tribute (for the living)
To Honor: Individual(s)
Location: in any city, Canada

Whatever you do ( Big or Small )

Thank you for making this planet a better place one action at a time !


AND REMEMBER, NOTHING IS TOO SMALL !


GOD BLESS YOU ALL !
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Posted: Feb 6, 2006 6:48pm

 

 
 
Content and comments expressed here are the opinions of Care2 users and not necessarily that of Care2.com or its affiliates.

Author

Paul Girardin
, 5, 1 child
Ottawa, ON, Canada
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Feb
18
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\\n\\r\\nHello my C2 Family, \\r\\nFirst let me say Thank You to those of you who have so sweetly fwd my posts. You are SO AWESOME!! I will never forget your help. Anytime I can repay the favour, please tell me. Second, my Submit button has disappeared lea...
Feb
13
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Wanted to say that I try not to do too many forwards to my Friends.  When I do forward an article or petition, I hope you k
Feb
6
by Dave C.
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\\njust found this group and in case no one in it has been to care2 recently they now let you donate to save rainforest land using butterfly credits...just one hundred credits to donate.....saving rainforests is one of the most important things we can ...
Feb
1
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Message to the President, and to the Congress:It\\\'s very simple. We can aim for a UNIVERSAL Standard of $15 an hour Minimum Wage for ALL - that would be {frugally} a living wage these days. One should not have to be employed, and on government assista...
Jan
28
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\\r\\n   & nbsp;   &n bsp;  Leonard Peltier ( LPDOC ) :\\r\\n        & nbsp;    Remembering Pete Seeger\\r\\n\\r\\n & nbsp;   &n bsp;   &nb sp;&nb...
Jan
26
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\\nThis is my Message that I send every week or so, to the President, my Representative, and my two Senators. {And in this instance, to the Vice President also.} \\r\\nThe Majority of the people of this country, approve that the President {and Vice Presi...
Jan
21
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\\r\\n   & nbsp;  Dr. Martin Luther King Jr. - Honored & Remembered\\r\\n\\r\\n&nb sp;    i\\\'m sharing this link to quotes and images of MLK\\r\\n  &nbs p;   to inspire \\r\\n\\r\\n  & nbsp; &n...
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20
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\\nHELP PLEASE NEED SOMEONE WHOSE NATIVE LANGUAGE IS SPANISH \\r\\nCAROL BASKINS AT BIG CAT RESCUE NEEDS TO ADD SPANISH TO BCR\\\'S SITES.  IS ANYONE ABLE TO DONATE SOME TIME TO HELP HER.  SHE DOES SUCH A GREAT JOB FOR HER SANCTUARY.  ...
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I feel Care2 members should KNOW about the \\\"work from home\\\" ads, RECRUITING \\\"MULES\\\" TO CARRY OUT ILLEGAL ACTIVITIES. Just like the Drug Cartels do... A person who was recruited unwittingly by one of these ads, was given in a seattleweekly.com arti...
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\\nEvery week or every other week, I send a Message to the President and to my Representative and Senators. This is the text of my latest:\\r\\nI have just sent the following message to President Obama; and I believe all Congresspersons need to hear it a...