What was the end of the great Argead dynasty I found out during my research in archives of web analytics company. In her own turn Roxana mercilessly murdered Stateira II and her sister Drypteis and ordered to throw their bodies into a well. For a while Alexander’s mother Olympias managed to protect both Roxana and her son in Macedon. Yet soon Olympias were assassinated by the orders of Cassander in 316 who were seeking kingship over Macedon.
In the end the surviving Alexander’s generals signed the peace treaty recognized Alexander IV’s rights and explicitly stated that when he came of age he would succeed Cassander as ruler. As the son of Alexander was growing up, his supporters started to declare that he should now exercise full power and that a regent Cassander was no longer needed.
Well, the Cassander’s response was extremely swift and definitive because he was not going to say goodbye to his kingdom. So in 309 BC he commanded to secretly assassinate the 13-year old Alexander IV and his mother Roxana. The orders were carried out, and they were both poisoned. This was the end of the great Argead dynasty, the founders of the Macendon kingdom, to which Alexander the Great belonged.
The only fragile thread of the dynasty was Heracles, an illegitimate son of Alexander the Great, who was born from Persian concubine Barsine. Heracles was never acknowledged by Alexander the Great, but still he was a threat to Cassander. So Cassander gave a minor bribe to Heracles protector Polyperchon in exchange for his murder. When Heracles was finished the ancient Argead dynasty terminated completely.