7:18 AM - Kangaroo beating videotaped, youth sought Case Details Kangaroo beating videotaped, youth sought unknown, WA (AU) Incident Date: Thursday, Sep 11, 2008 Disposition: Open Case Images: 2 files available Case Snapshot: Case ID: 14563 Classification: Beating Animal: other wildlife View more cases in WA (AU) Suspect(s) Unknown - We need your help! The RSPCA has launched an Australia wide search for a youth who was video taped beating a kangaroo as his friend looks on laughing. The video was sent to the RSPCA in WA and shows the youth using kickboxing style attacks on the kangaroo. In one scene the man pulls the kangaroo towards him and uses his knee to deliver a blow to the animal's chest. The final punch knocks the kangaroo to the ground where it appears to lie unconscious. The RSPCA says it is unclear whether the attack resulted in the death of the animal. A spokesman for the RSPCA, Richard Barry, says the organisation has launched a nationwide appeal to catch the men responsible for the footage. "We are appealing to every media outlet in Australia to help us track down the cowards behind the vicious attack on this kangaroo," he said. "Thankfully this sickening footage has now been removed from the website where it was first seen. The next stage is to ensure that those responsible for this film are brought to justice. "Only a coward would attack an injured and obviously terrified young animal much smaller than himself. We want these cowards to be caught, charged and prosecuted. "We are appealing to every media outlet in Australia to help us track down the culprits and we have also posted a photo of the youth at www.rspcawa.asn.au," he added. The RSPCA also welcomes the support of the Western Australia Police in finding the perpetrators of this senseless attack. Steve McLeod, a native wildlife expert, believes the animal was injured prior to being attacked: "The kangaroo is very disoriented. It is very unusual for a kangaroo to fight like that as they invariably flee. I would hazard a guess that it has been knocked over by the car and injured. Certainly it has been stunned in some way." The RSPCA across Australia has joined forces to launch a nationwide appeal to catch the cowards who shot this appalling footage. "We are appealing to every media outlet in Australia to help us track down the cowards behind the vicious attack on this kangaroo," said Richard Barry, spokesman for the RSPCA in WA. "Thankfully this sickening footage has now been removed from the website where it was first seen. The next stage is to ensure that those responsible for this film are brought to justice. "Only a coward would attack an injured and obviously terrified young animal much smaller than himself. We want these cowards to be caught, charged and prosecuted. "We are appealing to every media outlet in Australia to help us track down the culprits and we have also posted a photo of the youth at www.rspcawa.asn.au The RSPCA also welcomes the support of the Western Australia Police in finding the perpetrators of this senseless attack. "The RSPCA is sending a clear message that this behaviour is not only unacceptable, it is against the law. "People might think posting videos on the internet provides them some anonymity but the RSPCA is here to tell those people that when it comes to animal cruelty, we have zero tolerance and we will use every resource to track you down." If you know the identity of the youth in the video, contact your local RSPCA. Catch this cowardIn WA the number to call is (08) 9209 9300 In Queensland call 1300 852 188 In NSW call (02) 9770 7555 In ACT call (02) 6287 8100 In SA call (03) 8231 6931 In Tasmania (03) 6332 8200 In Victoria (03) 9224 2222 or email inspector@rspcavic.org.au Information will be treated as confidential. References * ABC News - Sept 11, 2008 * * RSPCA http://www.pet-abuse.com/cases/14563/WA/AU/

Dangerous Medicine: Examples of Animal-Based “Safety” Tests Gone Wrong

By John J. Pippin, M.D., and Kristie Stoick, M.P.H.

Biological differences between and within species require scientists to proceed with caution when interpreting the results of any experiment. Animals of different ages, sexes, developmental stages, and of different health status can all respond differently to experimental treatments. It is no surprise, then, that humans respond differently to administered pharmaceuticals than other animals. The surprise comes when scientists, physicians, and regulatory officials are willing to risk the health of patients by relying on animal experiments to predict the effects of drugs in humans—sometimes with grave results.

According to some estimates, adverse drug reactions are responsible for 2.2 million hospitalizations and 106,000 deaths annually.¹ Furthermore, as many as 50 percent of FDA-approved drugs are withdrawn or relabeled due to unanticipated side effects in humans.²³ Below are a few selected examples to illustrate the dire need for better, more human-specific drug safety tests. A shockingly low 56 percent of known human teratogens are positive in one of six species surveyed.

Thalidomide
Perhaps the most famous teratogen, this drug was given to pregnant women in the 1950’s to control nausea, causing more than 10,000 births with limb-reduction defects.^4,5 After thalidomide was withdrawn from the market, tests in pregnant mice, rats, and guinea pigs were negative; finally, one strain of rabbit (the New Zealand white rabbit) was found to be susceptible. Cats, hamsters, rats, and mice were later found to be sensitive only to extremely high doses.³

Oraflex, Opren (Benoxaprofen)
Even though year-long tests in rhesus monkeys6 gave no indication of risk, months after this non-steroidal anti-inflammatory (NSAID) was released onto the market in 1982, patients began experiencing severe liver toxicity and phototoxicity,^7,8 eventually resulting in withdrawl of the drug, but only after more than 3,500 serious adverse events and 60 deaths occurred in Britain alone.⁹

Flenac (Fenclofenac)
This NSAID, despite passing animal toxicity tests in 10 animal species (mice, rats, guinea pigs, ferrets, rabbits, cats, dogs, pigs, horses, and monkeys), produced severe liver toxicity in humans.¹⁰

Butazolidin (Phenylbutazone)
This NSAID is commonly used in equine medicine to reduce pain and inflammation, but in humans can produce serious phototoxicity,¹¹ as well as serious or fatal liver¹² or bone marrow¹³ disease. Bone marrow toxicity was demonstrated in human cell cultures after the drug was released and produced more than 10,000 fatal cases of aplastic anemia.^14-16

Cylert (Pemoline)
Fifteen children suffered acute liver failure after taking this attention deficit hyperactivity disorder treatment, and 12 of those cases resulted in liver transplant or death.¹⁷ No animal tests that showed an indication of hepatic toxicity could be found.

Rezulin (Troglitazone)
This drug, intended to treat type 2 (adult-onset) diabetes, was approved by the FDA in 1997. Rezulin lowered the blood sugar in rats without producing adverse effects, but reports of severe and even fatal liver failure appeared immediately after approval. Due largely to an aggressive investigation by the Los Angeles Times and after four label changes, Rezulin was withdrawn in 2000 after 391 deaths were attributed to the drug.¹⁸

Propulsid (Cisapride)
Propulsid was approved by the FDA in 1993 and was used primarily to treat gastric reflux in children. Heart rhythm disturbances had appeared in clinical trials, but not in animal studies. By 1995, heart rhythm deaths in children became evident through adverse events reports. The drug remained on the market with five label changes, until being withdrawn in 2000 after causing over 300 deaths.¹⁸

Inocor (Amrinone)
This short-term therapy option for patients with severe heart failure produced severe and sometimes fatal thrombocytopenia (decreased blood clotting ability) in humans, despite no evidence of this effect in 2-year-long animal tests. Only after approval, and only in marmosets and a very specific, metabolically compromised strain of rat, were similar effects found.⁷

Baycol (Cerivastatin)
Baycol was a popular drug approved in 1997 for the treatment of dyslipidemia (abnormal cholesterol levels), but it was withdrawn after substantial risk for severe or fatal rhabdomyolysis (muscle wasting) was revealed in patients. Muscle wasting was not seen in pre-clinical animal tests, including rats, mice, minipigs, dogs, or monkeys; only at very high doses were indications of effects on muscle tissue seen.¹⁹ The authors concluded that cerivastatin was well tolerated in all species. Post-withdrawal tests using rat and human muscle cells in vitro revealed that rat cells are 200 times more resistant to the drug’s effects.²⁰ Eventually more than 100 deaths were linked to cerivastatin.

Such a high error rate begs the question: How many possibly life-saving therapies have clinicians never investigated because of toxicities in other animal species? Penicillin, which was originally discovered in 1929, wasn’t used until 1939 because of its ineffectiveness in curing infected rabbits. If it had been “safety” tested in cats, guinea pigs, or hamsters, it would have been abandoned as toxic.²¹

Furosemide (Lasix) is one of our most important diuretics, used to reduce fluid retention during heart failure and other diseases. Though experiments in mice show extensive liver damage, decades of clinical use have proven its safety for humans.^22,23

One of our most relied-upon pain relievers, Aspirin (Acetylsalicylic acid), causes teratogenic malformations in mice, rats, dogs, cats, rabbits, and monkeys.³

What You Can Do

• More funding must be dedicated to the development of better, human-based drug safety tests. Write your federal legislators to explain this urgent need.
• Encourage the National Institutes of Health to fund studies using non animal methods, such as the examples listed at the right. Contact NIH here:
  Elias Zerhouni, Director
  National Institutes of Health
  9000 Rockville Pike
  Bethesda, MD 20892
• Support only health charities that fund non-animal research. A full list of those with the Humane Charity Seal of Approval can be found at www.HumaneSeal.org.

References
1. Lazarou et al. JAMA 1998 Apr 15;279(15):1200-5.
2. United States General Accounting Office (GAO) GAO/PEMD-90-15 Apr1990.
3. Bailey et al. Biogenic Amines 2005 19(2):97-145.
4. March of Dimes: http://www.marchofdimes.com/professionals/681_1172.asp
5. Rajkumar SV. Mayo Clinic Proceed 2004; 79:899-903.
6. Dahl SL and JR Ward. Phamacotherapy 1982;2(6): 354-66.
7. Eason et al. Reg Tox Pharm 1990;11:288-307.
8. Parke et al. Pol J Occ Med 1990;3(1):15-41.
9. Medawar C. BMJ 1982; 285:459-60.
10. Gad S.  J Am Coll Tox 1990;9:291-302.
11. Becker et al. Acta Derm Venerol 1996 Sep;76(5):337-40.
12. Peters. Tox Path 2005;33:146-154.
13. Neumuller J and M Tohidast-Akrad. Arzneimittelforschung 1994 May;44(5):636-41.
14. Wolfe S.  Lancet 1984;1:353.
15. Venning. BMJ 1983 Jan 15;286:199-202.
16. Venning. BMJ 1983 Jan 29;286:365-8.
17. FDA safety alert 1999: http://www.fda.gov/medwatch/safety/1999/cylert.htm
18. Willman D. Los Angeles Times, December 20, 2000.
19. von Keutz, E and G Schluter. Am J Cardiol 1998;82:11J-17J.
20. Johnson et al. Toxicol Appl Pharm 2004 Nov 1; 200(3):237-50.
21. Fleming, A. ATLA 1994;22:207-9.
22. Mitchell et al. Nature 1974 Oct 11;251(5475):508-11.
23. Hutcheon DE and G Leonard. J Clin Pharmacol J New Drugs 1967 Jan-Feb;7(1):26-33.

    reference URL:

http://www.pcrm.org/resch/anexp/dangerous_med.html

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