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3 Theories on Why Alzheimer’s Hits Women Harder Than Men

3 Theories on Why Alzheimer’s Hits Women Harder Than Men

Women who develop symptoms of Alzheimer’s disease typically face a faster rate of decline of their mental functioning than men in the same stage of the disease, according to a recent analysis.

Researchers from the University of Hertfordshire examined fifteen studies conducted on Alzheimer’s sufferers of both sexes and found that men with the disease regularly outperform women on tests that measured a senior’s memory capacity and their ability to perform verbal and visuo-spatial tasks (i.e. estimating distance and depth).

Previous research has shown that women are more likely to be diagnosed with Alzheimer’s disease than men, but investigation into how the disease affects the brains of the sexes differently has been sparse and conflicting.

The current study aimed to get a clearer picture of the gender-based differences of Alzheimer’s and the potential causes of these disparities.

Study authors concluded that there must be something about Alzheimer’s that puts women at a disadvantage. They offered several theories to explain why men and women with the disease experience mental decline at different rates:

  • Hormones wreaking havoc: Studies have shown that estrogen may act as a shield against Alzheimer’s disease in women. Thus, the estrogen loss that accompanies menopause could play a role in making women more susceptible to functional decline.
  • Men may have more robust reserves: Cognitive reserve has emerged as a proven buffer against symptoms of Alzheimer’s and other forms of dementia. As a gender, men may have more exposure to reserve-building activities (higher education, unique experiences, a challenging professional career) than women.
  • It could be in the genes: The primary genetic risk factor for Alzheimer’s disease—the APOE genotype—has been shown to have a more detrimental effect on the cognitive functioning of women than men.

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Alzheimer’s Hits Women Harder Than Men originally appeared on

Read more: Aging, Alzheimer's, General Health, Health, Healthy Aging, , , , ,

By Anne-Marie Botek, Editor

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+ add your own
10:19PM PDT on Jun 27, 2013

I hope the find an answer It is heartbreaking when a parent doesn't recognize their child. the same is true of course for a spouse/partner

11:08AM PDT on Jun 26, 2013


8:41PM PDT on Jun 25, 2013

Interesting findings but hope more in-depth studies are done soon.

11:55PM PDT on Jun 24, 2013

Interesting, hope they'll be more conclusive soon...

11:38PM PDT on Jun 23, 2013


2:10PM PDT on Jun 23, 2013

i did not know this--ty for the info.

6:56PM PDT on Jun 22, 2013

Thank you

2:40AM PDT on Jun 22, 2013


10:02PM PDT on Jun 21, 2013

I am so glad we are closer to finding this monster. I hope we can kill it, the loss of self is frightening, at least to me.

5:27PM PDT on Jun 21, 2013


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Disclaimer: The views expressed above are solely those of the author and may not reflect those of
Care2, Inc., its employees or advertisers.

people are talking

Thanks Editors. Cute, but frustrating for the kitten I sure.

Well, I find it hard to stop myself from telling a beautiful woman that she is beautiful...

great article


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