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Cayenne Pepper for IBS & Chronic Indigestion

Nearly 50 million Americans come down with food poisoning every year. Over a hundred thousand are hospitalized and thousands die every year just because of something they ate. If they had ordered something different or chosen something else at the grocery store, they or their loved one would be alive today. But in the vast majority of cases food poisoning manifests itself as little more than a case of “stomach flu”—a few days of pain, vomiting, diarrhea, and then it’s gone. So what’s the big deal?

Well, as described in this recent editorial in the American Journal of Gastroenterology, in many cases that acute infection can trigger a chronic “postinfectious functional gastrointestinal disorder” that can last for years or even forever—the two most common of which are irritable bowel syndrome and functional dyspepsia (chronic indigestion).

Up to 10% of people stricken with Salmonella, E. coli, or Campylobacter are left with irritable bowel syndrome. The thought is that the transitory inflammation during the infection leads to subtle but permanent changes in the structure and function of the digestive system, causing the lining of the gut to become hyper-sensitized. How do they determine if someone’s rectum is hypersensitive?

Innovative Japanese researchers developed a device to deliver repetitive painful rectal distention. Basically, the researchers hooked up a half-quart balloon to a fancy bicycle pump that was lubricated with olive oil, inserted it into the rectum and inflated it until the patients couldn’t stand the pain anymore. And those with IBS had a significantly lower pain threshold, significantly less “rectal compliance.”

Healthy people felt the pain where you’d expect to feel the pain with, effectively, a balloon animal in your butt. But many with IBS also experienced abdominal pain, indicating a hypersensitivity of the entire gut wall. Well, if that’s the problem, how can we desensitize the gut?

We learned in the cluster headache story about the ability of hot pepper compounds to deplete pain fibers of substance P, a neurotransmitter used for transmitting pain. It’s bad enough to have to rub hot peppers up your nose, where do you have to stick them for irritable bowel? Thankfully researchers chose the oral route.

The researchers concluded that “The results of this preliminary study indicate that the chronic administration of red pepper powder in IBS patients with enteric-coated pills was significantly more effective than placebo in decreasing the intensity of abdominal pain and bloating and was considered by the patients more effective than placebo, suggesting a novel way of dealing with this frequent and distressing functional disease.”

After 48 million cases of annual food poisoning, 10% may end up with IBS. Even more may end up with chronic dyspepsia—chronic indigestion. How do peppers work against that? You can’t use whole peppers because then you couldn’t blind a placebo, but if you give capsules of red pepper powder to folks suffering from chronic indigestion—about one and a half teaspoons a day worth—and compare that to a sugar pill, within a month their overall symptoms dropped, including their stomach pain and their feelings of being bloated. They had less nausea, too. The frequently prescribed drug Propulsid (cisapride) worked almost as well as the red pepper powder, and was considered generally well tolerated… that is, until it killed you. Propulsid was pulled from the market after causing dozens of deaths.

I explore another natural treatment for IBS in Kiwi Fruit for Irritable Bowel Syndrome.

If you missed Wednesday’s video of the day Hot Sauce in the Nose for Cluster Headaches?, it explains how hot pepper compounds work by depleting pain fibers of their substance P.

I’ve covered some of the long-term consequences of food poisoning in videos such as Poultry and Paralysis, Fecal Bacteria Survey, and Amnesic Seafood Poisoning. The meat industry is all over it, though: Check out Viral Meat Spray and Maggot Meat Spray. Why is it legal to sell meat tainted with our leading foodborne killer? Find out in Salmonella in Chicken & Turkey: Deadly But Not Illegal.

In health,
Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live year-in-review presentations Uprooting the Leading Causes of Death and More Than an Apple a Day.

Preventing & Treating Diarrhea With Probiotics
Prunes, Metamucil, or a Plant-Based Diet?
Boosting Gut Flora Without Probiotics

Read more: Colitis, Crohn's & IBS, Diet & Nutrition, Eating for Health, General Health, Videos, , ,

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Dr. Michael Greger

A founding member of the American College of Lifestyle Medicine, Michael Greger, M.D., is a physician, author, and internationally recognized speaker on nutrition, food safety, and public health issues. Currently Dr. Greger serves as the Director of Public Health and Animal Agriculture at The Humane Society of the United States. Hundreds of his nutrition videos are freely available at


+ add your own
1:55AM PST on Nov 9, 2013

Yum! I love Cayenne pepper.

3:06AM PST on Nov 8, 2013


1:47AM PST on Nov 7, 2013

Thank you :)

6:07AM PST on Nov 5, 2013

Spicy food kills my stomac. He is mixed up a bit here.

5:06AM PST on Nov 5, 2013


9:11PM PST on Nov 4, 2013

Thanks for this informative and interesting article.

2:57PM PST on Nov 4, 2013


2:12PM PST on Nov 4, 2013

This was very interesting since I do have IBS and I like spicey food, but was told, NO NO. I would like to know if the pills are available and if so, where.

11:52AM PST on Nov 4, 2013

This article doesn't make any sense, it's a mish-mash of ideas, with no links to specific scientific studies. What is the author trying to say?
There are several causes of indigestion, and for some of them, like acid reflux, peppers are a big no-no.

2:32PM PST on Nov 3, 2013


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