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The End of Morphine & Heroin Addiction?

The End of Morphine & Heroin Addiction?

An international team of scientists has discovered a key mechanism that causes opioid addiction  — and there’s a drug that can selectively block that addiction response, without damaging the brain or interfering with pain relief.

According to a study by the University of Adelaide and the University of Colorado, published in the Journal of Neuroscience, the drug (+)-naloxone may be able to help drug addicts and patients with severe pain alike. It works by shutting down a specific immune system receptor, the Toll-Like receptor 4 (TLR4). Ordinarily, these receptors bind to opiates (like morphine) and then amplify the body’s addictive response to these drugs.

In a press release, the lead author of the study, Dr. Mark Hutchinson from the University of Adelaide, describes their findings:

“Our studies have shown conclusively that we can block addiction via the immune system of the brain, without targeting the brain’s wiring. Both the central nervous system and the immune system play important roles in creating addiction, but our studies have shown we only need to block the immune response in the brain to prevent cravings for opioid drugs. [...]

The drug (+)-naloxone automatically shuts down the addiction. It shuts down the need to take opioids, it cuts out behaviours associated with addiction, and the neurochemistry in the brain changes – dopamine, which is the chemical important for providing that sense of ‘reward’ from the drug, is no longer produced.”

While the drug naloxone has been used to treat emergency overdoses for years, this is the first clear evidence that (+)-naloxone (a variant of naloxone) might be able to prevent and aid opiate addiction in pain patients and drug addicts. Clinical trials of (+)-naloxone co-formulated with morphine, intended for patients with severe pain, may even begin within the next 18 months.



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3:42AM PDT on Mar 17, 2015


11:42PM PDT on Jun 16, 2013

This blog is very informative the stuff you provide I really enjoyed reading.

2:34PM PDT on Oct 13, 2012

awesome if true and good

4:40AM PDT on Sep 6, 2012


2:46PM PDT on Sep 3, 2012

I hope it works and helps people. It's so scary thinking about this type of addiction.

9:37AM PDT on Sep 2, 2012

Addiction is a cruel. very misunderstood affliction. If people could stop then they would. They KNOW that they are killing themselves....thats the control addiction has over both body & mind

9:40PM PDT on Sep 1, 2012

Sorry didn't proof read before posting.

The first paragraph should continue after ... meditation may offer a more holistic approach to a better balanced lifestyle

The language of war only serves to keep opposite sides entrenched in what is a health problem for some people.

9:28PM PDT on Sep 1, 2012

I think few need a new drug to replace the old drug, there are always side effects and long term concerns, diet, exercise, what I would call cognitive education or meditation.

Also, sadly some of the comments here seem to reflect a lack of critical thinking skills by the author. This article offers some tips:

Thank you for your time.

9:09AM PDT on Sep 1, 2012


7:33AM PDT on Sep 1, 2012

Thanks for bringing this to light. It is too sson for a comment at this stage.

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Disclaimer: The views expressed above are solely those of the author and may not reflect those of
Care2, Inc., its employees or advertisers.

people are talking

Thanks for the spread of awareness. Hope we get such info for each region of the world.

Thank you for posting.

Thanks for posting.

There are so many conflicting reports on depression, especially regarding medication; it is difficul…


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