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Israeli Researchers Stop The Brain From Aging To Prevent Alzheimer's

Health & Wellness  (tags: Israel medical researchers, , named NT219 )

- 1583 days ago -
Forever young? Neurodegenerative disease, such as Alzheimer's and Parkinson's, are most likely to occur in older people. Researchers at the Hebrew University of Jerusalem, alongside an Israeli startup called TyrNovo, have made a major step towards halting

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Beth S (330)
Sunday January 19, 2014, 6:32 pm
Forever young? Neurodegenerative disease, such as Alzheimerís and Parkinsonís, are most likely to occur in older people. Researchers at the Hebrew University of Jerusalem, alongside an Israeli startup called TyrNovo, have made a major step towards halting these diseases Ė by essentially stopping the brain from aging.

The researchers, led by Doctor Ehud Cohen, found that TyrNovoís novel and unique compound, named NT219, selectively inhibits the process of aging in order to protect the brain from neurodegenerative diseases, without affecting lifespan. This is a first and important step towards the development of future drugs for the treatment of various neurodegenerative maladies.

Human neurodegenerative diseases such as Alzheimerís, Parkinsonís and Huntingtonís diseases share two key features: they stem from toxic protein aggregation and emerge late in life. As humans age, the mechanism regulating protective mechanisms that prevent the manifestation of the toxic proteins start to fail, making the elderly exposed to disease.

From worms, to mice, to men

Cohenís first breakthrough in this area occurred when he discovered, working with worms, that reducing the activity of the signaling mechanism conveyed through insulin and a hormone called IGF1, constituted a defense against the aggregation of a protein which is mechanistically-linked with Alzheimerís disease. Later, he found that the inhibition of this signaling route also protected Alzheimerís-model mice from behavioral impairments and pathological phenomena typical to the disease. In these studies, the path was reduced through genetic manipulation, a method not applicable in humans.

Dr. Hadas Reuveni, the CEO of TyrNovo, a startup company formed for the clinical development of NT219, and Profesor Alexander Levitzki from the Department of Biological Chemistry at the Hebrew University, with their research teams, discovered a new set of compounds that inhibit the activity of the IGF1 signaling cascade in a unique and efficient mechanism, primarily for cancer treatment, and defined NT219 as the leading compound for further development.

Now, in a fruitful collaboration Cohen and Reuveni, together with Cohenís associates Tayir El-Ami and Lorna Moll, have demonstrated that NT219 efficiently inhibits IGF1 signaling, in both worms and human cells. The inhibition of this signaling pathway by NT219 protected worms from toxic protein aggregation that in humans is associated with the development of Alzheimerís or Huntingtonís disease.

Treating the untreatable

Recently, Cohenís laboratory obtained an ethical approval to test the therapeutic efficiency of NT219 as a treatment in Alzheimerís-model mice, hoping to develop a future treatment for neurodegenerative disorders that currently cannot be treated.

Cohen is a member of the Department of Biochemistry and Molecular Biology, at the Institute for Medical Research Israel-Canada in the Hebrew University of Jerusalemís Faculty of Medicine. The project was funded by the Rosetrees Trust of Britain. The findings were published this week in the journal Aging Cell.

Madhu Pillai (22)
Sunday January 19, 2014, 9:46 pm
Same old story, if its not their way its the highway....

Helen Porter (39)
Monday January 20, 2014, 12:49 am
(((HUGS to ISRAEL)))

I think we Old Timers need what Israel is altruistic enough to be giving us.

I remain delighted with Lumosity, which is on internet....a few of the scientific games. These with my rapidly rising scores were enough to convince me to join so I could play all those games. It makes getting smarter and keeping high points fun.

My brain is getting smarter and smarter. LOL I make her work out in the "brain gymn"
every day. LOL

I've been with Lumosity for about a year now and hope to be
soon a volunteer in their scientific research.

Lumosity chases my boogie men away.

I am grateful to Creator for this fun way to scientifically exercise the brain.

Israel is so altruistic!

and especially
Israel's G-D.

I'll be gone for about a week yet. Everything is Okay.


. (0)
Monday January 20, 2014, 12:52 am
𝖓𝖔𝖙𝖊𝖉. 𝖙𝖍𝖆𝖓𝖐𝖘 𝖇𝖊𝖙𝖍!

Carol Dreeszen (346)
Monday January 20, 2014, 12:55 am
Israel again shows the world they have the leading edge in technology and discoveries! Good for Israel!

Hilary S (65)
Monday January 20, 2014, 1:34 am
shame the BDS crowd will have to miss out on this wonder.

Jonathan Harper (0)
Monday January 20, 2014, 4:05 am

. (0)
Monday January 20, 2014, 9:44 am
More good stuff from the Israelis and what have the "Palestinians" given us lately?

. (0)
Monday January 20, 2014, 9:50 am
Thanks Carol and Michael.

Judith Hand (55)
Monday January 20, 2014, 10:40 am
Noted. Go, Israel! Their science is so amazing; it's crazy that someone - for that reason alone - should try to disable them further.

Winn Adams (179)
Monday January 20, 2014, 10:48 am

Barbara K (60)
Monday January 20, 2014, 1:01 pm
Hooray for Israel. We need actual cures for these diseases. Not just pills to enrich the pharmaceutical industry and keep people medicated for every disease and ailment.

Birgit W (160)
Monday January 20, 2014, 3:13 pm
Will wait and see.

Theodore Shayne (56)
Monday January 20, 2014, 3:25 pm

Nelson Baker (0)
Monday January 20, 2014, 4:32 pm
I hope it works.

Arlene C (42)
Monday January 20, 2014, 7:27 pm

Beth S (330)
Monday January 20, 2014, 8:03 pm

There are SO many inventions, advances, cures and wonderful things that Israel does. The problem is that there are only so many articles I can post. It's important for people to see what's going on in the Muslim world and to hear the other side from what the anti-Semites have to say about Israel. To them, there is nothing Israel can do.

What have the Palestinians given us? We sink billions of dollars into their economies and they give the world more victimhood, more terrorism, more demands.

Israel does amazing things, and it gives and gives and gives to the world the many blessings that its brilliant, dedicated citizens do.

It is fighting for its very survival, and in so doing it is not perfect, it is a work in progress, but it's LIGHT years ahead of anything in the petro-dollar rich Arab world in the way of human rights, sciences, civil liberties, etc.

These countries don't have anywhere the pressure Israel does, and they have nothing but contempt for people. People, especially non-Muslims, are just pawns to be moved till they can reach ultimate power -- a global Caliphate.

There are so many more accomplishments and blessings that Israel gives. Yes, I only post one every couple of weeks, but there are way too many to post. What a dilemma.

Helen Porter (39)
Monday January 20, 2014, 8:44 pm

Helen Porter (39)
Monday January 20, 2014, 9:01 pm
Miracle, I've been trying to get something to post for hours and I couldn't. I somehow got logged off and could not get logged back in no matter what I tried.

Yet, here I am. So I sent messages to my friends just minutes ago that I couldn't get logged in to Care2...again !!! . I decided to try one more time I am.

I am grateful.

Now, I gotta change my name from AWAY to Kallah. LOL


I wanted to share something with you. I have my grocery list of items that "smarten up the brain" according to research I have done. Maybe yes.....Maybe no.....

Here ya go!

brussel sprouts
beans (chick peas, soy, kidney beans)
collard greens, cherries
chocolate (dark)
collard greens
grains (whole)
grapes (red)

That's my shopping list.


Now, let's see if this comment will also print.

Either way, I am grateful.

Helen Porter (39)
Monday January 20, 2014, 9:02 pm

reft h (66)
Monday January 20, 2014, 10:27 pm
Thanks to the Israelis for their research

Ondine J (134)
Monday January 20, 2014, 11:04 pm
Noted ,thanks

Julie W (32)
Tuesday January 21, 2014, 12:22 am
Yet again, Israel leads the way in medical research. I wonder if their scientists get better funding than other countries?

Inge Bjorkman (202)
Tuesday January 21, 2014, 1:25 am
Science is the future, soon we can move us in time and space.
Ban all religion.


M B (62)
Sunday January 26, 2014, 7:42 am
good work.

marie C (163)
Tuesday January 28, 2014, 5:19 pm
Dear Zee not too sure about the cheese some bad reports on soy also but I guess there is always something we have to listen to our doctors and ourselves and work it out between the two
I wish you well

Bryna Pizzo (139)
Friday February 21, 2014, 6:07 pm
Thank you! (n, p, t)
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