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Newly-Identified Exercise Gene Could Help With Depression

Science & Tech  (tags: depression, mice, research, gene, exercise gene, brain, anti-depression )

- 2914 days ago -
Depression affects 16 percent of the population in the United States. Boosting an exercise-related gene in the brain works as a powerful anti-depressant in mice--a finding that could lead to a new anti-depressant drug target.

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Eduardo L. (101)
Monday December 3, 2007, 8:21 pm
The action of one gene in particular--VGF--was greatly enhanced by exercise. Moreover, administering VGF functioned like a powerful anti-depressant, while blocking VGF inhibited the effects of exercise and induced depressive-like behavior in the mice.

"Identification of VGF provides a mechanism by which exercise produces antidepressant effects."

Eduardo L. (101)
Monday December 3, 2007, 8:22 pm
"This information further supports the benefits of exercise and provides a novel target for the development of new antidepressants with a completely different mechanism of action than existing medications."
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