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Soy Infant Formula and Seizures in Children with Autism: A Retrospective Study
04/02/14

Autism is a cluster of complex neurobiological disorders known as autism spectrum disorders. The core features include impairments in social interaction and communication, and repetitive stereotyped behavior. Autism is estimated to occur in 1 in 88 children with prevalence 4.7-fold higher in males [1]. The etiology of autism is not known but genetic as well as environmental factors likely affect the severity of symptoms [4]. Our findings in rodent models of neurological disease demonstrate that soy ingestion during a critical period of sensory development significantly increases seizure activity [5]. Mouse colonies are typically maintained on Purina-type lab chows, which are grain-based with their protein content derived from soybeans [6]. Soybeans are rich in phytoestrogens, plant estrogens”, which are transferred to offspring through the placenta as well as maternal milk [7]. The steady-state level of phytoestrogens found in serum (2,338±531 ng/mL) of Purina-fed mice is greater than endogenous estrogen levels by at least 30,000-fold and has immense potential to affect development [8]. The soy phytoestrogen daidzein was identified as a seizure-promoting ingredient in mice [5]. Thus, we hypothesized that the use of soy-based infant formulas could be contributing to seizure incidence in autism and other neurodevelopmental disorders.

Seizures are a common phenotype in many neurodevelopmental disorders including fragile X syndrome, Down syndrome and autism. We hypothesized that phytoestrogens in soy-based infant formula were contributing to lower seizure threshold in these disorders. Herein, we evaluated the dependence of seizure incidence on infant formula in a population of autistic children. Medical record data were obtained on 1,949 autistic children from the SFARI Simplex Collection. An autism diagnosis was determined by scores on the ADI-R and ADOS exams. The database included data on infant formula use, seizure incidence, the specific type of seizure exhibited and IQ. Soy-based formula was utilized in 17.5% of the study population. Females comprised 13.4% of the subjects. There was a 2.6-fold higher rate of febrile seizures a 2.1-fold higher rate of epilepsy comorbidity [3.6% versus 1.7%, OR = 2.2, 95% CI = 1.4.7] and a 4-fold higher rate of simple partial seizures [1.2% versus 0.3%, OR = 4.8, 95% CI = 23] in the autistic children fed soy-based formula. No statistically significant associations were found with other outcomes including: IQ, age of seizure onset, infantile spasms and atonic, generalized tonic clonic, absence and complex partial seizures. Limitations of the study included: infant formula and seizure data were based on parental recall, there were significantly less female subjects, and there was lack of data regarding critical confounders such as the reasons the subjects used soy formula, age at which soy formula was initiated and the length of time on soy formula. Despite these limitations, our results suggest that the use of soy-based infant formula may be associated with febrile seizures in both genders and with a diagnosis of epilepsy in males in autistic children. Given the lack of data on critical confounders and the retrospective nature of the study, a prospective study is required to confirm the association.

Citation: Westmark CJ (2014) Soy Infant Formula and Seizures in Children with Autism: A Retrospective Study. PLoS ONE 9(3): e80488. doi:10.1371/journal.pone.0080488

Editor: Stephen D. Ginsberg, Nathan Kline Institute and New York University School of Medicine, United States of America

Autism is a cluster of complex neurobiological disorders known as autism spectrum disorders. The core features include impairments in social interaction and communication, and repetitive stereotyped behavior. Autism is estimated to occur in 1 in 88 children with prevalence 4.7-fold higher in males [1]. The etiology of autism is not known but genetic as well as environmental factors likely affect the severity of symptoom [4]. Our findings in rodent models of neurological disease demonstrate that soy ingestion during a critical period of sensory development significantly increases seizure activity [5]. Mouse colonies are typically maintained on Purina-type lab chows, which are grain-based with their protein content derived from soybeans [6]. Soybeans are rich in phytoestrogens, plant estrogens which are transferred to offspring through the placenta as well as maternal milk [7]. The steady-state level of phytoestrogens found in serum (2,338±531 ng/mL) of Purina-fed mice is greater than endogenous estrogen levels by at least 30,000-fold and has immense potential to affect development [8]. The soy phytoestrogen daidzein was identified as a seizure-promoting ingredient in mice [5]. Thus, we hypothesized that the use of soy-based infant formulas could be contribution to seizure incidence in autism and other neurodevelopmental disorders.

This post was modified from its original form on 02 Apr, 2:01

How to spread the news
02/11/14

This is really awfull, i did write many hosst announcements, but they dissapeared, luckely Care2 memebers like Tj is busy with this fact, in which hakckers have their hand...... i will never understand what makes them do this kind of shit, what is so imporatant in making ppl do or write for nothing, do u have a great laugh about it hacker???/, anyway, i will try to put in news or alerts aain, as soon as it is needed, for now this is my message to u all, share, write and make it happen, what ever u think is important and forget the smallminded hacker poor ppl they need to get a real life........

Members and news
05/02/11

Dear members, somehow this is strange to put down here, because the members who left will not read this, but i would like ask all of you, to give me a notice when u leave the group GREENFOREVER, since the beginning only 2 members left, but i would like to know why and ask for explanation, maybe i could do something about it, maybe someone who needs attention, maybe i am able to learn from the critisism they would provide me, maybe its someone who has not time left, being ill, or taking care for someone else and due to this no energy left to be kept busy via our group/care2, anyway, i hope u wont mind i started this subject and ofcourse i hope nobody leaves.

Another problem is the denial in submition of my shares, or submitted stories in this group, it is either my computer or something from Care2, i hope to solve this problem anyhow, maybe u have some advises for me.

Thank u very much for ur attention, please let me know if u think something could be better, or if u have green stories, good news, advise and so on, please come in sometimes and share ur news, also here somehow my shares are not going to other groups, this will be me, i dont know how to do that, how to obtain this possebillety.........

Have a great time, thank u for caring and antisipate in so many good causes, think green, live green and u will be green:)welcome to all my sincere apologies for the bad english, :)marjolein

Members
09/21/10

Dear members, it was a great week in France -Bretagne-, that is very special, its the part which was connected once to the UK, when all land was more conected to eachother, now it is part french, part kind off keltisch, so different from the rest off France, it was sunny, lots off flowers everywhere, and all thoose roudabounds, u have nowadays instead off crossings, when driving a car, they were pretty, trees, flowers, or statues off farmers, shoemakers, milkmaids and so on, a joy to go around.
So back to normal, eh, thats is.....back to dayly life........the world off minors and to much, the world off loud unrightly voices and silence, the world off abused earth and animals, ppl and children, back to.................a somtimes lonley life, sometimes a pretty, colourfull and actif life, i hope u all had a good time, in clicking and signing and act, but also some fun and sunshine.
The last 4 weeks 3 members left the group, they dont say goodbye, just delete themselves, i dont know what to think about it, or feel about it, better not see it as a negatif sign, maybe u want to help me out, when u know something about this and also ask ur friends to become a member, if u think the group should do or act more.. tell us, if u know some good advice, so give it, if u want to write down some story, please do, thank u for ur effort, please ask anyone to sign the 3 petitions, they will be here till end off 2010 and more members would be nice........maybe someone could tell me, how to bring this news to all, i still dont know if anyone is able to read/getting this.........thank u, warm hugs, marjolein



This post was modified from its original form on 21 Sep, 9:25
holidays i will be gone till 21 september
09/09/10

Dear members, i will not be here for about 10 days, tomorrow i will go for a holiday, so i will not be online, i hope u still will share what u can/want inhere and make some movement according to environment and greenliving, or human facts and so on, thank u for being a member, have a fine time in between, take care, warm hugs:)marjolein

Bees in Usa and also the rest off the world
08/31/10

Dear members, i saw a documentaire on tv, it was about bees, did u know 80 percent of the bee-population has gone/disapeared, in the USA, that in the european cities bees are more healthy, because there the flowers and trees are under protection and not in touch with pesticides, that bees have not one virus, but many, also fungus and so many other deseases at the same time. Overal they get so sick, they have memoryloss and their inside looks like that off a severe aids-sufferer, their immumesystem is gone and this all because numerous pesticide poisend their fragile bodies and caused the aids-like illnesses. What the USA does is import bees from Australia, but that does not help enough and actually only makes more problems as more bees get ill and seem to lose their life due to damaging the fields they get their food. So now the only thing we can do is protest, write, create petitions and make this aware to all and everybody in the world, because if bees are gone, nature will suffer and dissapear, earth will turn into a stonelike dry and unliveble surroundings. If any off u have a suggestions, so do and make it so, our earth needs us in this, we cannot take it anymore, we have to protest strongly, at any cost, in every way, for all, this is not the only problem, due to pesticides but it is the most important reason to stop the use off any pesticide, even if this means, we will not have acces to all we are used to, even when we have to reduce our demands for variaty in all kinds of food, actually we should go back to grandmothers time and eat less, eat more of the same, only what would grow naturelike, with seasons and so on. Well, it took me, this tv-programm, i was stunned and felt like a bit off me died, what are we doing, why is this not in a solvingstate, when this is already known since 10 years or even more, maybe we dont deserve to live, but nature should not be the victum because of that, so again, please forward this, act and tell me, how can i participate in the healing off natue according to the bee-population..... excuses for my english, i am dutch by native. Marjolein Soederhuizen

member, invite a friend
06/10/10

Dear members, may i suggest something, to make this group bigger, please invite one friend, share some inhere and enjoy it all...................thank u

Have a great weekend

Warm hugs for u all, u who make this site possible, keep the flow going and are so wellminded and kindhearted to all the voiceless on this earth.

WHAT ABOUT US
04/19/10

please listen to the song, WHAT ABOUT US, offcourse u know it, but u have to listen to the words again, to be into the caring and saving earth where ever u can, if it is people or nature, animals or the other voiceless.......sit down, listen and.......try to act, i always have to cry, when hearing this song, not only because Micheal has gone, but also, because the wordl is on a so bad system..i know u probebly do all u can, but just once for us, do more, for one day, dont be offended, just make a difference in a different way, one day, with someone else, alone, in a group, with ur family, ur children, ur neighbours, thank u so much, for considering, for caring, for being inhere, for what u do and are, thank u, thank u, throw that stone in the water and make the circle get bigger and bigger, till u reached all u know, again, thank u.

 

 http://www.youtube.com/watch?v=8pPkiEEYt8w

 

Love is a way, the only way, for earth and mankind, u are spreading it, be proud, i am for sure, for u and me.

not to good
04/16/10

DEAR MEMBERS, i am sorry to let u down, but as i am not that good, in health, i have to apologize for the not being here and sharing green news, next week, i will be able to make more possible inhere and for all, share some good news according to green living, being and sharing, for now, i wish u all a fine weekend, i will be back in about the 21 off april, warm hugs for u all.enjoyment and fun are the doors to more happines...............:)marjolein

green is healthy
01/29/10

did u know, that if u are a positif thinker, u care and are responseble for ur own life, u will be more healthy and clearminded, but whats more important, u make the world healthier too, to be an example for everyone in ur surrounding will not be ur greatest concern, yet u get more enrgy, because off what u do, other are also trickered to do same, or simelar actions, its like a child, doulbes his father and mother for a big part.

So, now that u are that example, why not try to make the next step and do that every day, just small steps, like no plastic bag anymore, like choosing for unpacked fruit and fresh food, like refucing double package, or turn down any evgeatabels which are chemical treaten, if u try to find a shop nearby, where thoose profucts are available, u maybe have to go a bit futher, but, u are that same example again, above that, u make the pollutering products factories/ companies do something about it, they have to answer to a demand, u are the boss, u are the one who can demand, are able to demand and have to demand, even when no store is around, u could try to get ur products with a (small f) farm, or u can tell any shopowner to get what u want, at least u can try.

Be the one, who helps changing the polluting system, tiny steps, but in the end a long walk and u will not walk alone.

I apologize for any faults, i am dutch by native, so excuse me.

Kopenhagen, attention.
12/18/09

15000 ppl from all over the world are gathered together to talk about our climate and earth, talk about?, yes, they will try to make decisions, rules, but, most off the talks still will be about, how to earn money and save earth, this is not an option, when the system as we know it now goes on, the rcih world will eat the rest off the earth, whats left?.....within 100 years no much, yet i see another issue rising, as 10 years ago, or 20, when i founded my foundation anti pollution, ppl laughed, so the most important is, that ppl want to know or talk about it now and that we all have to act upon it, it will take some time, but....earth herself and our health will force us, a pity, it would have been better, to help ourselves much sooner, but, we all can do our things, know what u buy, refuce caged meat, no package around fresh food, every day, u try to learn, know and do more then the day before, u will feel so much better and then u can talk about it, what u did, what u gonne do, how u are an example for others and inspire them, just by doing the small things u know u can do, if we all would do that, half off the problem would be gone, the other half has to follow, CAUSE, U ARE THE ONE, U ARE THE CONSUMER, U ARE THE DICIDER.

we are able to stop some off the pollution
12/13/09

In ur own surroundings, u are able to do what u can, just think, before u buy a product, buy he ones which are not responseble for pollution, there are so many alternative products, so, as a cosumer u are the one, who has to take the responseblillety now, thus showing the goverment, they should actually refuce the pollution by putting an end in earning money, with while creating pollution.
Thank u for acting the right way, we can only make it work together!



This post was modified from its original form on 13 Dec, 18:30