Alternatives for Testing
Alternatives to the use of animals in toxicity testing include replacing animal tests with non-animal methods, as well as modifying animal-based tests to reduce the number of animals used and to minimize pain and distress. Non-animal tests are generally faster and less expensive than the animal tests they replace and improve upon.

To date, several non-animal test methods have been formally validated and accepted by some countries as replacements for an existing animal test. Examples include:

• An embryonic stem cell test, using mouse-derived cells to assess potential toxicity to developing embryos, has been validated as a partial replacement for birth-defect testing in rats and rabbits.(6)
• The 3T3 Neutral Red Uptake Phototoxicity Test, which uses cells grown in culture to assess the potential for sunlight-induced (“photo”) irritation to the skin.
• Human skin model tests such as the validated EpiDerm™ test, which has been accepted almost universally as a total replacement for skin corrosion studies in rabbits.(7)
• The use of human skin leftover from surgical procedures or donated cadavers can be used to measure the rate at which a chemical is able to penetrate the skin.
• The use of a clinical patch test in human volunteers, which can confirm that a chemical will not cause irritation or allergic skin reactions.(8)

For more detailed information about non-animal test methods that are available or under development, visit ECVAM.jrc.it and StopAnimalTests.com.

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