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Pain Killers Blunt The Immune Response November 12, 2009 12:47 AM

Common Pain Relievers May Reduce Body’s Ability to Make Antibodies, Dilute Flu Shot Effectiveness November 3, 2009

“By decreasing antibody synthesis, NSAIDs also have the ability to weaken the immune system, which can have serious consequences for children, the elderly and immune-compromised patients.”

Taking a common pain killer such as Advil, Tylenol, Aleve, Motrin, aspirin, etc. before or after receiving a flu shot will likely both reduce the vaccine’s effectiveness and have a negative effect on your immune system, say researchers at University of Rochester Medical Center.

“What we’ve been saying all along, and continue to stress, is that it’s probably not a good idea to take common, over-the-counter pain relievers for minor discomfort associated with vaccination,” says Richard P. Phipps, PhD, a professor of Environmental Medicine, Microbiology and Immunology & Pediatrics at University of Rochester (NY) Medical Center. “We have studied this question using virus particles, live virus, and different kinds of pain relievers, in human blood samples and in mice - and all of our research shows that pain relievers interfere with the effect of the vaccine.”

Dr. Phipps, who has been studying this issue for years, recently presented his latest findings to an international conference on inflammatory diseases. His research has tested whether production of antibodies using a cell culture system was blunted by over-the-counter pain relievers. He found that a variety of pain relievers – even though Tylenol and Advil have different ingredients - seemed to dilute the production of necessary antibodies to protect against illness.

Similar findings were reported in the Oct 17 issue of The Lancet by researchers in the Czech Republic. They found that giving acetaminophen, the active ingredient in Tylenol, to infants weakens the immune response to vaccines.

Many of the pain relievers in question are classified as NSAIDs or nonsteroidal anti-inflammatory drugs, which act in part by blocking the cyclooxygenase-2 (cox-2) enzyme. Blocking the cox-2 enzyme is not a good idea in the context of vaccination, however, because the cox-2 enzyme is necessary for the optimal production of B-lymphocytes.

Therefore, when a person takes a medication to reduce pain and fever, he or she might also inadvertently reduce the ability of B cells to make antibodies.

Phipps and colleagues have also demonstrated that timing of the administration of pain relievers is important, according to a study published Apr 5, 2009 in Cellular Immunology (“Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells”).

They exposed human cells and mice to ibuprofen, Tylenol, aspirin and naproxen (Aleve) in amounts comparable to doses commonly used by millions of Americans every day to prevent or treat pain and fever, or arthritis, or to prevent heart attack and stroke.

• Treatment during the earliest stages of inflammation – or when the first signs of pain, swelling, redness or fever would occur – had the most detrimental effects on the immune system, the study noted.

• The connection between NSAIDs and antibody production is still being actively pursued. Phipps said researchers believe ibuprofen, in particular, affects lymphocytes’ ability to produce antibodies.

• Meanwhile, until a full clinical trial provides a clearer picture, Phipps urges regular users of NSAIDs to be aware of the risks.

“NSAIDs are one of the most commonly used drugs; they are recommended for all age categories, are prescribed for relieving transient pain or in cases of serious inflammatory diseases,” Phipps said. “By decreasing antibody synthesis, NSAIDs also have the ability to weaken the immune system which can have serious consequences for children, the elderly and the immune-compromised patients.”

The U.S. Public Health Service has funded Phipps’ studies.

Source: University of Rochester Medical Center news release, Nov 3, 2009 (modified)

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