START A PETITION 25,136,189 members: the world's largest community for good
START A PETITION
x
1,517,957 people care about Health Policy

Can Breast Milk Help Prevent HIV Transmission?

Can Breast Milk Help Prevent HIV Transmission?

 

When it comes to HIV transmission and breast feeding, the prevailing wisdom has been that a HIV infected mother risks passing on the virus to her child, if the child was not already infectedin utero, through her breast milk. However, a new study has added weight to scientists’ suspicions that breast milk may in fact contain properties that block the transmission of HIV and thus that the infection risk must come from some other variable.

Scientists have long been aware of breast milk’s ability to block HIV transmission in vitro, that is to say in isolated experiments that do not directly involve living subjects. However, breast milk’s inhibitory properties had not been demonstrated in vivo, or with living subjects . This, for Angela Wahl of the University of North Carolina, created a line of investigation that needed to be addressed–was breast milk really the culprit for early-life transmission, or does breast milk have transmission retarding properties?

So to test inhibitory power of breast milk, Wahl’s team took test subjects, in this case mice that had humanized bone marrow, liver tissue and thymus tissue, referred to as BLT mice, and one group of sample swallowa HIV-laced fluid absent of breast milk , and breast milk tainted with the HIV virus.

They found that in the mice that were given the tainted breast milk, HIV transmission did not occur.

Reports the study’s authors in the study abstract:

In stark contrast to the robust transmission of cell-associated HIV after oral exposure in the absence of breast milk, cell-associated HIV was not capable of establishing a productive infection when oral exposures occurred in the presence of breast milk. Specifically, we did not detect HIV RNA in the plasma of BLT mice that were exposed orally to HIV-infected cells re-suspended in the breast milk of donors 1 or 2 at any time point post-exposure (Figure 7D). Furthermore, the lack of HIV transmission was confirmed at necropsy when no HIV DNA was detected in the peripheral blood or tissues of any BLT mouse exposed to cell-associated HIV in the presence of human breast milk (Table 3). Collectively, these data demonstrate that BLT mice are susceptible to oral transmission of cell-associated HIV and that human breast milk possesses innate factors that can potently inhibit oral transmission of both cell-free and cell-associated HIV.

This sets the stage for further study into the role that breast milk, alongside retrovirals, may be able to play in HIV prevention strategies. To reiterate though, it does not demonstrate that breast milk alone could be some kind of miracle cure for the global HIV crisis–at least, not yet.

Says study leader Dr Victor Garcia in a comment to the AP:

“This study provides significant insight into the amazing ability of breast milk to destroy HIV and prevent its transmission.

“No child should ever be infected with HIV because it is breastfed. Breastfeeding provides critical nutrition and protection from other infections, especially where clean water for infant formula is scarce.

“Understanding how HIV is transmitted to infants and children despite the protective effects of milk will help us close this important door to the spread of Aids.”

What is it in breast milk that acts as a barrier method helping to prevent HIV transmission then? Scientists are as yet unsure, though the study’s authors do point out that when in previous in vitro studies an inhibitory effect was not demonstrated, scientists were using skimmed breast milk rather than whole breast milk. This leads to several tantalizing avenues of inquiry. Scientists speculate that if they are able to pin down precisely what it is in breast milk that is acting as a barrier to infection, they may be able to use that so as to stop other infection methods such as sexual transmission.

So why do children become infected with HIV during early childhood if it is not in fact from breast milk? Researchers are not quick to draw conclusions on this point, but a number of theories exist, including that the mothers may have cracked or broken areas surrounding the nipple which may create the potential for HIV transmission.

Chiefly, this study suggests that the associated benefits of breast feeding, that is to say protections from infections that result in diarrhea, pneumonia and sepsis, may not have to be sacrificed under the false assumption that breast milk is the culprit for HIV transmissions, and that through also administering antiretroviral drugs it may be possible for HIV-infected mothers to still harness breast milk’s well established benefits in child health protection.

Read the full write-up of the study here.

 

Related Reading:

Catholic Hospital Denies Gay Man HIV Medicine

Today is National Black HIV/AIDS Awareness Day – Stars Speak Out

Gay, Lesbian and HIV Grassroots Growing in China

Read more: , , , , ,

Image used under the Creative commons Attribution License, with thanks to Ania I Artur Nowaccy.

have you shared this story yet?

some of the best people we know are doing it

17 comments

+ add your own
9:51PM PDT on Jun 17, 2012

Thanks.

9:43PM PDT on Jun 17, 2012

Thanks!

9:33PM PDT on Jun 17, 2012

Thanks.

8:30PM PDT on Jun 17, 2012

I was raised on the Playtex nurser bottle but if I knew that breast milk protected one from HIV / Aids I wished that I had had the opportunity to suck tit when I was a child.

8:00PM PDT on Jun 17, 2012

interesting, but very confusing how the transmission doesn't occur with breast milk...wonder if it's similar to how HIV doesn't easily pass via saliva due to the presence of a specific enzyme.

6:26PM PDT on Jun 17, 2012

This sounds like great news! Thank you for this very interesting and informative article.

10:01AM PDT on Jun 17, 2012

How could someone write this article without the use of the word "antibodues?"
Please don't use the word "tainted" when discussing disease transmission, infection, etc. This is an archaic word with a lot of superstitious baggage, and has no place in scientific writing.

Steve Williams has a lot of interesting credentials, but a background in science is not one of them. Please, Care2, don't leave the vital task of conveying scientific information to the public to well-meaning amateurs.

8:54AM PDT on Jun 17, 2012

This sounds like good news. HIV is passed through body fluids. It is good that breast milk is not one of them.

8:47AM PDT on Jun 17, 2012

Wow! Who'd a' thunk? I'd say a lot more study needs to be done, but, then, we all knew that breastmilk was beneficial.

8:16AM PDT on Jun 17, 2012

There could be a HIV partial solution right there: give breast milk to HIV-infected people. Now if we could have the FDA get rid of its strange objections to breast milk...

add your comment



Disclaimer: The views expressed above are solely those of the author and may not reflect those of
Care2, Inc., its employees or advertisers.

ads keep care2 free

meet our writers

Steve Williams Steve Williams is a passionate supporter of Lesbian, Gay, Bisexual and Trans (LGBT) rights, human... more
Story idea? Want to blog? Contact the editors!
ads keep care2 free

more from causes




Select names from your address book   |   Help
   

We hate spam. We do not sell or share the email addresses you provide.