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Do Soybeans Really Offer HIV Resistance?

Do Soybeans Really Offer HIV Resistance?

Could the humble soybean really provide us with a new and more effective HIV inhibitor that comes without the drug resistance problems found in current therapies?

Researchers at the George Mason-based National Center for Biodefense and Infectious Diseases and the Department of Molecular and Microbiologyhave found that there is potential if further tests on genistein, a compound derived from soybeans and other plants, continue to show positive results.

“Instead of directly acting on the virus, genistein interferes with the cellular processes that are necessary for the virus to infect cells,”said lead researcher Yuntao Wu. “Thus, it makes the virus more difficult to become resistant to the drug. Our study is currently in its early stage. If clinically proven effective, genistein may be used as a complement treatment for HIV infection.”

HIV hijacks the surface sensors of our cells in order to replicate itself. Genistein, the compound derived from soybeans, is known as a “tyrosine kinase inhibitor.” That means it can block communication from a cell’s surface sensors to a cell’s interior. As such, it would retard HIV infiltration and proliferation in the body, effectively hampering the virus from spreading.

As mentioned above, genistein may have other benefits too. Due to the fact that it is a plant-based compound, it has the potential to offer a HIV treatment that could sidestep what is known as drug toxicity.

Many HIV patients are forced to take a combination of several drugs in order to stop HIV advancing in their bodies. As a result, HIV sufferers may become ill as a result of their daily regimen of drugs.

In addition to this, there is also the fact that HIV can mutate and become resistant to the drugs a sufferer is currently using.Genistein potentially would not be subject to such constraints or offer the toxicity side effects of other drugs.

Now, this isn’t the first time that the soybean compound has been eyed as a potential contender for a new wave of HIV treatments. Researchers have known of soybean’s potential HIV inhibiting properties sinceat least 2008, and a2011 Chinese study investigated the potential of the mini-black soybean as a protease inhibitor that, again, could slow HIV spread in the body.

Soybeans have also been found to contain the potential for anti-cancer drugs, thoughextracting the precise compounds for refinement has been difficult.

Sadly though, it seems unlikely that a daily diet of genistein-rich food such as soybeans could, on its own, provide sufficient concentrations of the compound to offer HIV resistance.

“Although genistein is rich in several plants such as soybeans, it is still uncertain whether the amount of genistein we consume from eating soy is sufficient to inhibit HIV,” Wu is quoted as saying.

Wu and team are now attempting to research exactly the amounts that would be needed to offer health benefits and whether refining a drug treatment based on the compound will be viable. Alternatively, it may be that soybeans and other genistein-rich plants could be engineered to offer greater concentrations of genistein but, of course, this comes with its own set of limiting factors, not least of which is the potential wider environmental impact.

With an eye to the viability of treatment, genistein would never be a stand-alone HIV inhibitor, and certainly not an HIV cure.

What it does have the potential to be, however, is an inexpensive HIV inhibitor that might come with fewer medical issues than the current, harsh variety of drug treatments.

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Image credit: Thinkstock.

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4:02PM PST on Nov 19, 2014

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5:02PM PDT on Oct 2, 2014

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2:17PM PDT on Oct 2, 2014

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6:21PM PDT on Jun 4, 2014

noted

6:11PM PDT on Jun 4, 2014

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8:07PM PDT on Mar 13, 2014

MY HIV HEALING TESTIMONY

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5:16AM PST on Feb 19, 2014

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Kind Regards

1:42PM PST on Feb 18, 2014

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7:11PM PST on Feb 1, 2014

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3:45PM PST on Jan 24, 2014

Truthfully i was tested HIV + positive last 3 years. I keep on managing the drugs i usually purchase from the health care agency to keep me healthy and strengthen, i tried all i can too make this disease leave me alone, but unfortunately it keep on eating me up this is what i caused myself, for allowing my frank make sex to me insecurely without protection, although i never knew he is HIV positive. So last few 4 days i came in contact with a lively article on the internet on how this Powerful Herb Healer get her well and healed. So as a patient i knew this will took my life 1 day, and i need to live with other friends and relatives too. So i copied out the Dr PAUL the traditional healer’s via email: okonofua_solution_tem99@hotmail.com and I mailed him immediately, in a little while he mail me back that i was welcome to his temple home were by all what i seek for are granted. I was please at that time. And i continue with him, he took some few details from me and told me that he shall get back to as soon as he is through with my work. I was very happy as heard that from him. So Yesterday, as i was just coming from my friends house, Dr EMEN called me to go for checkup in the hospital and see his marvelous work that it is now HIV negative, i was very glad to hear that from him, so i quickly rush down to the nearest hospital to found out, only to hear from my hospital doctor called HARRISON that i am now HIV NEGATIVE. I jump up at him with the test note, he ask me how does

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