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Only Man to be Cured of HIV May Still Show Traces of Virus

Only Man to be Cured of HIV May Still Show Traces of Virus

 

Timothy Brown made medical history when, after a bone marrow transplant, all traces of HIV in his system seemed to be eradicated, leading to wide scientific debate and excitement. Now, Brown is again the subject of scientific inquiry after tests show there may after all still be traces of HIV in his body.

Reports NPR:

But new data presented last week in Spain raise a question about whether there are minute traces of HIV in some tissues–not whole virus capable of replicating, but pieces of viral genes.

Researchers have combed through 9 billion of Brown’s cells, retrieved from his blood, lymph nodes, spinal fluid and intestinal tract. Four different labs could find no trace of HIV in his blood cells. But three groups, using tests at the very limit of detectability, think they have identified bits of HIV genetic material — two from blood plasma and one from intestinal cells.

[...]

“Although the subject has had intermittent evidence for HIV persistence in some assays in some laboratories,” the researchers wrote in a summary, “the extremely low levels of virus which were detected, while pushing the limits of sensitivity and specificity … make it impossible to conclude that the subject remains HIV-infected.”

What does the appearance of HIV-infected cells mean for Ray’s cure?

While some doctors have now begun to speculate that Brown may have been reinfected with the virus, they remain in a minority.

Others have suggested that the new findings are in fact due to contaminated lab conditions, pointing out that the cell fragments do not completely match the HIV strain Brown was originally infected with. Indeed, Douglas Richman of the University of California, San Diego, is quoted as saying, “If you do enough cycles of PCR (polymerase chain reaction), you can get a signal in water for pink elephants.”

However, the majority of scientists, while highlighting that Brown’s case is unprecedented and so any talk surrounding what might be going on must be taken as theorizing, wish to focus on the fact that even if there are traces of the virus in Brown’s system, they are not actively capable of replicating. This means that, functionally speaking, the Berlin patient’s cure is still active: Brown’s HIV symptoms were eradicated with the bone marrow transplant and have yet to return.

Indeed, the scientist who presented the findings at a HIV/AIDS talk in Spain, Steven Yukl of the University of California, San Francisco, has accused the media and some other scientists of misrepresenting what his team presented.

According to the AFP, Yukl had in fact been very careful to characterize the findings as indicative that further research will be necessary:

Yukl “highlighted the difficulties that they and several labs they collaborated with have had determining if Brown truly had eradicated the virus from his body,” said the ScienceInsider report.

“There are some signals of the virus and we don’t know if they are real or contamination, and, at this point, we can’t say for sure whether there’s been complete eradication of HIV,” Yukl was quoted as saying by ScienceInsider.

Timothy Brown, 45, was the recipient of several bone marrow transplants in Berlin in 2007 and 2008 to treat leukemia. The blood cells used during the transplant came from a donor with a genetic mutation that made his cells immune to HIV. Around 10% of Caucasions are thought to be immune to HIV. Just how this immunity comes about is not yet fully understood, though recent research confirms the suspicion that a mutation of the gateway protein CCR5 is at least partially involved. The patient used in Brown’s case did have the CCR5 mutation, and when scientists returned to Brown’s test results post-transplantation they were shocked to discover he remained without viral rebound, even after discontinuation of antiretroviral therapy. Brown, to this day, continues to live free of HIV symptoms.

This led scientists to declare in 2010 that a cure for HIV had been achieved, whereby they set about attempting to analyze and replicate the conditions that led to Brown’s cure.

This new information, while the subject of great media interest and scientific debate, may be important then as it could allow scientists a clue to exactly what process occurred in Brown’s body to bring about the eradication of HIV symptoms.

 

Related Reading:

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Today is National Black HIV/AIDS Awareness Day – Stars Speak Out

Gay, Lesbian and HIV Grassroots Growing in China

 

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Image used under the Creative Commons Attribution license with thanks to Tod Huffman.

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38 comments

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3:24PM PDT on Aug 26, 2014

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2:55PM PDT on Apr 16, 2014

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12:56PM PDT on Jul 10, 2013

It is unfortunate that the author misrepresents the 2009 report in the New England Journal of Medicine, "Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation", as an announcement of a 'cure'. This is very misleading, and may even encourage risky behavior. Four years later, in 2013, there is still no cure!

While early detection and 'cocktail' anti-retroviral therapy can often achieve long-term control of HIV, many high-risk folks do not even know their HIV (sero-positive) status. Knowledge of the facts about HIV, safe sex, and safe IV drug use, and the will to act responsibly, is what is needed, not false hope for a quick and easy "cure".

3:33PM PST on Nov 5, 2012

thanks

2:30PM PDT on Jun 19, 2012

This topic is very serious. To prevent the HIV virus, we already know what not to engage in and what not to do to contract it. The Bible is clear on this. Medicines, eventually, there will be a shortage or no medicine at all the way this economy is going and trust me, deaths will be on the rise when and if that time comes.

6:54AM PDT on Jun 19, 2012

Is hope on the horizon? Hopefully yes.

9:20PM PDT on Jun 18, 2012

An interesting article. Thank you

6:39PM PDT on Jun 18, 2012

good article

6:25PM PDT on Jun 18, 2012

Hopefully, the traces of HIV foubnd in Timothy Brown are just viral remants and not viable infection. Evidently, more research will need to be done. Maybe the research will help benefit and draw support to the National Marrow Donor Program (NMDP) and its Be The Match campaign. More research will have to be conducted to learn if bone marrow transplant might be a successful treatment for HIV one day.

5:40PM PDT on Jun 18, 2012

CCR5 is a unique mutation. I wonder if it exists in the human population because of previous exposure to HIV related viruses in the distant past?

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