Why is the HIV Vaccine Taking So Long?

One of the most infamous viruses in modern history burst onto the scene in 1981, when clinicians started observing strange cases of immunodeficiency in patients who had no obvious reasons for their ill health. By 1983, two independent groups of researchers had found the retrovirus responsible, and today, it’s known as the human immunodeficiency virus (HIV). 30 years after it was discovered, we still don’t have a vaccine that can effectively prevent HIV infection.

What’s the holdup?

There are several contributing factors to the problems with successfully developing an effective HIV vaccine. This wily little retrovirus is determined to live and to keep spreading, and like other viruses, it’s extremely adept at evolving, shifting and staying one step ahead of medicine. That means it poses a unique challenge to the researchers who want to stop it in its tracks; we may have successfully eradicated smallpox, but can we do the same to HIV?

One of the problems with HIV is that it’s not a uniform virus. It has a number of subtypes, known as clades, found in various populations around the world. Each clade is different, and vaccinating against one will not necessarily protect a patient from other strains. Thus, vaccine developers have to look for strands of DNA in infected cells that are as common to as many clades as possible (as an RNA virus, HIV penetrates cells and hijacks their functions to force them to turn out new copies of itself), with the goal of sensitizing the patient’s immune system and teaching it to go on the attack when it spots those genetic sequences.

That’s tough to do, especially since HIV regularly evolves, exchanging, changing and dropping genetic material. Some vaccines haven’t been very effective, while others have actually increased susceptibility to HIV, which is exactly the opposite of what researchers want to see. Thus, any successful vaccine has to consider the complex issue of differing clades and evolution.

One approach has relied on taking antibodies from infected patients and introducing them into the bodies of healthy patients. If the body accepts the antibodies, they’ll flag the virus and infected cells for destruction, sending in the cleanup crews of the immune system to take out the HIV. However, antibody therapy is extremely expensive and time-consuming, which makes it less practical to implement on a global scale.

Researchers have also been exploring ways to use the body’s T cells, an important part of the immune system. So far, none of the vaccines they’ve developed with T cells in mind have been effective, but they have managed to reduce the viral load in already infected patients, which is an extremely positive sign. Limiting the presence of HIV in the body means less health problems for the patient, and lowers the risk of full-blown AIDS.

Assuming researchers manage to develop a vaccine that is generally effective against most strains of HIV — and many seem to think they’ll succeed eventually — the road will be far from over. First, the virus needs to be taken out of the lab environment and tested in conditions with escalating size, complexity and states. Many medical developments barely make it out of the lab before it becomes apparent that they have many problems, and they can’t realistically be brought to market. It could take ten years or more, even with fast-tracked research, development and regulatory permissions, to turn a promising vaccine in the lab into one that would be accessible to consumers.

And when it does become available to the public, it’s likely to be sold at a high price point, reflecting the expenses involved in producing it. Even though many researchers are engaged in their work for the public good and some of the facilities researching HIV vaccines are publicly owned, private industry is interested too, and if it can win the patent race, it will charge a pretty penny for HIV vaccination. This in turn may spark a difficult conversation about medical patents and the availability of potentially life-saving medical advances.

Photo credit: Army Medicine.

99 comments

Manson E.
Manson E.about a month ago

HELLO,I'M Anna ramos by name, I WANT TO SHARE MY EXPERIENCE OF HOW I GOT CURED FROM HIV BY HERBAL MEDICINE. It may sound
strange! For the past 5years i have spent a lot of money in buying anti-retroviral medicines to strengthen my immune system and keep me healthy, until i read an article on the internet about an Africa Herbalist who uses herbs and roots to cure HIV and all kind of diseases. Thought i never believed he can cure HIV, but i decided to give it a try because i was desperate. Then i sent a message to the him on his email DR.ABUYAHERBALCURE@GMAIL.COM He prepared herbal medications and send it to me through DHL COURIER SERVICE and i took it as he instructed. 11days after, i went to the hospital to do a checkup, the result came out and i tested NEGATIVE. I’m sharing this with you, because i believe there’s someone out here who also desire to have this cure. feel free to send a message to him on his email DR.ABUYAHERBALCURE@GMAIL.COM or call, AND ALSO CHAT WITH HIM THROUGH VIA WhatsApp OR IMO CHAT +2347039225049, and am sure he will be willing to help you and you will also have a testimony to share. please inform other victims about this.

SEND
Manson E.
Manson E.about a month ago

HELLO,I'M Anna ramos by name, I WANT TO SHARE MY EXPERIENCE OF HOW I GOT CURED FROM HIV BY HERBAL MEDICINE. It may sound
strange! For the past 5years i have spent a lot of money in buying anti-retroviral medicines to strengthen my immune system and keep me healthy, until i read an article on the internet about an Africa Herbalist who uses herbs and roots to cure HIV and all kind of diseases. Thought i never believed he can cure HIV, but i decided to give it a try because i was desperate. Then i sent a message to the him on his email DR.ABUYAHERBALCURE@GMAIL.COM He prepared herbal medications and send it to me through DHL COURIER SERVICE and i took it as he instructed. 11days after, i went to the hospital to do a checkup, the result came out and i tested NEGATIVE. I’m sharing this with you, because i believe there’s someone out here who also desire to have this cure. feel free to send a message to him on his email DR.ABUYAHERBALCURE@GMAIL.COM or call, AND ALSO CHAT WITH HIM THROUGH VIA WhatsApp OR IMO CHAT +2347039225049, and am sure he will be willing to help you and you will also have a testimony to share. please inform other victims about this.

SEND
James F.
James F.7 months ago

I am JAMES from SOUTH AFRICA, I Never
believed i was ever going to be HIV
Negative again,Dr takuta has given me reasons to
be happy, i was HIV positive for 2years and all the
means i tried for treatment was not helpful to me,
but when i came on the Internet i saw great
testimony about Dr takuta on how he was able to
cure someone from HIV, this person said great
things about this man, and advice we contact him
for any Disease problem that Dr takuta can be of
help, well i decided to give him a try, he requested
for my information which i sent to him, and he tod
me he was going to prepare for me a healing
portion, which he wanted me to take for days,and
after which i should go back to the hospital for
check up, well after taking all the treatment sent to
me by Dr takuta i went back to the Hospital for
check up, and now i have been confirmed HIV
Negative, friends you can reach Dr takuta on any
treatment for any Disease he is the one only i can
show you all up to, reach him on dr takuta on his
email.......... takutaspellalter@gmail.com
call or whatsapp him
_______ 27788634102

SEND
James F.
James F.7 months ago

I am JAMES from SOUTH AFRICA, I Never
believed i was ever going to be HIV
Negative again,Dr takuta has given me reasons to
be happy, i was HIV positive for 2years and all the
means i tried for treatment was not helpful to me,
but when i came on the Internet i saw great
testimony about Dr takuta on how he was able to
cure someone from HIV, this person said great
things about this man, and advice we contact him
for any Disease problem that Dr takuta can be of
help, well i decided to give him a try, he requested
for my information which i sent to him, and he tod
me he was going to prepare for me a healing
portion, which he wanted me to take for days,and
after which i should go back to the hospital for
check up, well after taking all the treatment sent to
me by Dr takuta i went back to the Hospital for
check up, and now i have been confirmed HIV
Negative, friends you can reach Dr takuta on any
treatment for any Disease he is the one only i can
show you all up to, reach him on dr takuta on his
email.......... takutaspellalter@gmail.com
call or whatsapp him
_______ 27788634102

SEND
James F.
James F.7 months ago

I am JAMES from SOUTH AFRICA, I Never
believed i was ever going to be HIV
Negative again,Dr takuta has given me reasons to
be happy, i was HIV positive for 2years and all the
means i tried for treatment was not helpful to me,
but when i came on the Internet i saw great
testimony about Dr takuta on how he was able to
cure someone from HIV, this person said great
things about this man, and advice we contact him
for any Disease problem that Dr takuta can be of
help, well i decided to give him a try, he requested
for my information which i sent to him, and he tod
me he was going to prepare for me a healing
portion, which he wanted me to take for days,and
after which i should go back to the hospital for
check up, well after taking all the treatment sent to
me by Dr takuta i went back to the Hospital for
check up, and now i have been confirmed HIV
Negative, friends you can reach Dr takuta on any
treatment for any Disease he is the one only i can
show you all up to, reach him on dr takuta on his
email.......... takutaspellalter@gmail.com
call or whatsapp him
_______ 27788634102

SEND
James F.
James F.7 months ago

I am JAMES from SOUTH AFRICA, I Never
believed i was ever going to be HIV
Negative again,Dr takuta has given me reasons to
be happy, i was HIV positive for 2years and all the
means i tried for treatment was not helpful to me,
but when i came on the Internet i saw great
testimony about Dr takuta on how he was able to
cure someone from HIV, this person said great
things about this man, and advice we contact him
for any Disease problem that Dr takuta can be of
help, well i decided to give him a try, he requested
for my information which i sent to him, and he tod
me he was going to prepare for me a healing
portion, which he wanted me to take for days,and
after which i should go back to the hospital for
check up, well after taking all the treatment sent to
me by Dr takuta i went back to the Hospital for
check up, and now i have been confirmed HIV
Negative, friends you can reach Dr takuta on any
treatment for any Disease he is the one only i can
show you all up to, reach him on dr takuta on his
email.......... takutaspellalter@gmail.com
call or whatsapp him
_______ 27788634102

SEND
Uduehi G.
Past Member 1 years ago

I am from U.S.A, I was diagnosed of hiv disease (Lou Gehrig’s disease) in 2011 and I have tried all I can to get cured but all to no avail, my life was gradually coming to an end, until i saw a post in a health forum about a herbal doctor from Africa call DR HAZZAN who prepares herbal cure to cure hiv/ and all kind of diseases including HIV, MND, Epilepsy, Leukemia, Asthma, Cancer, Gonorrhea etc, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email, he prepared an hiv herbal portion and sent it to me via courier service, when i received this herbal portion, he gave me step by step instructions on how to apply it, when i applied it as instructed, i was cured of this deadly disease within 7 days, I could not walk or talk understandably before but after i took the herbal cure as he instructed i regained strength in my bones and i could talk properly unlike before, I am now free from the deadly disease, all thanks to Dr Osauyi. Contact this great herbal doctor via his email dr.hazzanherbalcentre@gmail.com or you can call his cell phone on 2348169340571

SEND
Past Member
Past Member 1 years ago

Hello everyone here in this forum i am so glad that i have this great opportunity to come out here and share my testimony on how Dr Molemen was able to cure me totally from Hiv disease, i have been suffering from this Disease for approximately 4 Years now, i have tried various ways to get rid of this Virus out of my body, i have also purchase for Medical treatment from my doctor but they all failed, sometime back now while i was browsing the Internet i found some good quote concerning Dr Molemen Herbal Medicine, and how he has been using it to save souls from Different Disease including Cancer, someone also said she was been cured of Hiv from his medicine, and they gave out his contact details in case anyone needs his help, i decided to contact Dr Molemen and i told him about my Hiv illness he told me not to worry that he was going to send me his herbal medicine all i was to do is to send him my personal details and also my home address so he can post the Medicine to me, actually i did all that was required by this Man, i took the medicine just as prescribe by him, he told me to go for check up in the hospital which i did and to my great surprise my Doctor told me the Hiv Virus was no longer there, i even went to other hospital for better confirmation its was still the same thing, Today i am so happy that i am Negative again, Dr Molemen has given me reasons to share tears of Joy, you can reach to Dr Molemen on his email address at ( drmolemenspiritualtemple@gmail.com / dr.mol

SEND
Rosse David
Past Member 2 years ago

A day that i will never forget is the day i was cure by Dr okosisi for my hiv aid How can I explain this to the world that there is a man who can cure HIV/aids I was HIV over since 7year I have being into HIV drug I can’t anymore I decide to look for help then I found this woman post write about this great man Dr.Okosisi telling people about him that this man have cured to HIV I don’t believe that because all I have in mind is HIV had no cure, thank god for my life today am HIV negative through the power of Dr.Okosisi I contacted this man for help because who write about him drop an email of the man I pick the email and emailed him for the cure this man told me what to do about the cure well am from Australia this man cast a curing spell on me and he told me that he will call me after the cure is done truly he did I was cured for 45mins spell what a wonderful man this DR.Okosisi if you need his cured just email him now Okosisilovespell@gmail.com/okosisilovespell@yah…/okosisilovespell@hotmail.com

SEND
Rosse David
Past Member 2 years ago

A day that i will never forget is the day i was cure by Dr okosisi for my hiv aid How can I explain this to the world that there is a man who can cure HIV/aids I was HIV over since 7year I have being into HIV drug I can’t anymore I decide to look for help then I found this woman post write about this great man Dr.Okosisi telling people about him that this man have cured to HIV I don’t believe that because all I have in mind is HIV had no cure, thank god for my life today am HIV negative through the power of Dr.Okosisi I contacted this man for help because who write about him drop an email of the man I pick the email and emailed him for the cure this man told me what to do about the cure well am from Australia this man cast a curing spell on me and he told me that he will call me after the cure is done truly he did I was cured for 45mins spell what a wonderful man this DR.Okosisi if you need his cured just email him now Okosisilovespell@gmail.com/okosisilovespell@yah…/okosisilovespell@hotmail.com

SEND