Boost Serotonin Naturally

A strange letter was recently published in the Journal of Neuropsychiatry and Clinical Neuroscience suggesting fruit as a treatment for depression. It starts out detailing how bad the disease can be; how abnormally low levels of neurotransmitters like the “happiness hormone” serotonin in the brain may be responsible; and that we now have SSRI drugs like Prozac that appear to work by boosting serotonin levels. However, these medications can carry significant side effects, so the researchers suggested a novel strategy: How about using “high-content sources of serotonin to provide our body with these substances,” such as “plantains, pineapples, bananas, kiwis, plums, and tomatoes.”

Since when do plants have animal neurotransmitters? Since forever, I was surprised to learn. In my 2-min video Human Neurotransmitters in Plants I show how plants may contain levels of dopamine, serotonin, and melatonin at concentrations high enough to actually alter levels in our bloodstream. We don’t need serotonin in our blood, though; we need it in our brain. Serotonin can’t cross the blood-brain barrier, but the precursor to serotonin can. This precursor is an amino acid called tryptophan that we get from our diet.

Back in the 70’s experiments showed that when people were given specially concocted tryptophan deficient diets, their mood suffered. They became irritable, annoyed, angry, and depressed. Likewise, you can give people tryptophan pills to improve their mood, and, not surprisingly, it became a popular dietary supplement…until people started dying from something called eosinophilia–myalgia syndrome.

As I note in my 2-min video The Wrong Way to Boost Serotonin, EMS, an incurable, debilitating, and sometimes fatal flu-like neurological condition can be caused by the ingestion of tryptophan supplements. It may have been due to some unknown impurity, but better safe than sorry. Instead of supplements, there are dietary strategies one can use to improve mood.

When people think tryptophan, they think Thanksgiving turkey, but researchers at MIT dispelled those myths about a decade ago. Tryptophan is one amino acid among many found in proteins, and they compete with one another for transport across the blood-brain barrier into the brain. Since tryptophan is present in most animal proteins in relatively small quantities it gets muscled out of the way. When we eat plant foods, though, the carbohydrates trigger a release of insulin that causes our muscles to take up many of the non-tryptophan amino acids as fuel, potentially leaving our tryptophan first in line for brain access.

Animal foods can even make things worse. In an experiment I describe in my 2-min video A Better Way to Boost Serotonin, those given a turkey/egg/cheese breakfast experienced a drop in tryptophan levels, whereas those given a waffle/orange juice breakfast saw their levels rise. This may actually explain the carbohydrate cravings one sees in PMS—your brain may be trying to get you to boost tryptophan levels to feel better. One study I cite concluded “Consumption of a carbohydrate-rich, protein-poor evening test meal during the premenstrual period improved depression, tension, anger, confusion, sadness, fatigue, alertness, and calmness scores among patients with premenstrual syndrome.” Check out today’s video pick above for the final video in this four-part series.

The findings of better mood scores in those eating vegetarian is consistent with both cross-sectional and interventional findings I’ve reported previously. In addition to the drop in brain tryptophan levels associated with animal product consumption, arachidonic acid present in animal foods may also contribute to negative mood states through an inflammatory mechanism. See, for example, my videos Plant-Based Diet & MoodInflammatory Remarks About Arachidonic Acid, and Chicken, Eggs and Inflammation.

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In health,
Michael Greger, M.D.

Image credit: semarr / Flickr

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Elena Poensgen
Elena Poensgen6 months ago

Thank you

Elisa F.
Elisa F.2 years ago

Thanks for sharing.

Summerannie Moon
Summerannie M.3 years ago


Malgorzata Zmuda
Malgorzata Zmuda3 years ago

dzięki za info

Michele Wilkinson

Thank you

Varcolac Veroscarius

This is greta for bipolar disorders!.

Gianni K.
Gianni K.3 years ago

In the article it doesnt say that most of the serotonin obtained through foods gets used only by the gut.

The chemical structure of serotonin obtained from foods, doesnt pass the bloodbrain barrier, so the brain dosn't get a boost of serotonin.

In this article it says clearly this and also it explain the best methods to raise the serotonin in the brain, naturally!

Anyway, the serotonin neurotransmitter is still a foreign ground even today, so most of the things you will read are theories.

Leena K.
Leena K.4 years ago

interesting info, thanks!

J.L. A.
JL A.4 years ago

good to know

Uddhab Khadka
Uddhab Khadka4 years ago

Thank you.