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GOOD NEWS FOR KNEES: Groundbreaking Israeli Advance Regenerates True Cartilage for Arthritis


Health & Wellness  (tags: Arthritis technology, CartiHeal, cartilage scaffolding, Israel )

Beth
- 588 days ago - israel21c.org
Novel implant provides a scaffold for the body to regenerate true joint-protecting cartilage. CartiHeal's trademarked Agili-C can be implanted in a single-step arthroscopic procedure. In clinical studies, it was shown to regenerate true hyaline cartilage



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Beth S. (323)
Wednesday January 16, 2013, 7:43 pm

"If you get a cut, break a bone or scrape an elbow, your bloodstream brings the injury all the necessary nutrients for healing. But if your cartilage gets damaged, you’re out of luck. This flexible soft tissue that cushions joints – especially in the knee – has no blood vessels and therefore little ability to heal itself.

However, a privately held Israeli medical device company is now offering a safe and effective, novel off-the-shelf cartilage regeneration solution in a global market worth an estimated $1.6 billion annually.

CartiHeal’s trademarked Agili-C can be implanted in a single-step arthroscopic procedure. In clinical studies, it was shown to regenerate true hyaline cartilage (the most abundant type of cartilage in the human body) after six months.

Founder and CEO Nir Altschuler tells ISRAEL 21c that this is a breakthrough in the field — the “Holy Grail” in orthopedics — because other experimental treatments generate only “hyaline-like” cartilage, which is actually a non-lasting fibrous tissue rather than the real deal.

“Our clinical results, to date, confirm rapid cartilage and bone formation, as clearly visible on MRIs and X-rays,” says Altschuler. “Patients are reporting significant improvement in pain level and return to normal function, including sports.”

The implant has earned the European Union’s CE Mark of approval, and the company is currently running post-marketing clinical studies at leading centers in Europe.

Cartilage can’t self-repair

There are approximately 1.2 million cartilage repair procedures performed annually worldwide, and these surgeries mainly aim for pain relief since it hasn’t been possible until now to regenerate true hyaline cartilage.

Altschuler says Agili-C has the potential to heal the problem at an early stage and halt further joint degeneration, and therefore might have the potential to prevent the need for more radical procedures, such as knee replacement, down the road.

The implant provides a scaffold that enables stem cells to climb up from the bone marrow, form vessels within the scaffold and regenerate tissue, Altschuler explains.

Within a few months, the top layer becomes cartilage while the bottom layer becomes bone – each identical to the body’s own tissues. The regenerated cells gradually dissolve the implanted scaffold and the joints are nearly as good as normal.

The first patient to receive Agili-C was a 47-year-old Slovenian man, a former athlete whose knee cartilage was damaged due to a volleyball injury six years before the June 2011 surgery. Unable to enjoy sports, he suffered on and off from knee swelling and pain.

Six months after receiving the Agili-C implant, the patient was on the ski slopes. A year from his surgery, he completed a 180K cycling marathon, according to company officials.

“The X-ray and MRI images are promising,” says Altschuler. “At six months you can see signs of cartilage formation and at a year it is nearly fully regenerated. The newly formed cartilage is hyaline cartilage, the body’s native cartilage, distinguished by its specific type of collagen.”

Altschuler founded CartiHeal in 2009 as a portfolio company of Peregrine Ventures’ Incentive Technological Incubator. Today, CartiHeal is backed by a recent financing round of up to $10 million from Accelmed, Access Medical Ventures and Elron."
 

Beth S. (323)
Wednesday January 16, 2013, 7:47 pm
"If you get a cut, break a bone or scrape an elbow, your bloodstream brings the injury all the necessary nutrients for healing. But if your cartilage gets damaged, you’re out of luck. This flexible soft tissue that cushions joints – especially in the knee – has no blood vessels and therefore little ability to heal itself.

However, a privately held Israeli medical device company is now offering a safe and effective, novel off-the-shelf cartilage regeneration solution in a global market worth an estimated $1.6 billion annually.

CartiHeal’s trademarked Agili-C can be implanted in a single-step arthroscopic procedure. In clinical studies, it was shown to regenerate true hyaline cartilage (the most abundant type of cartilage in the human body) after six months.

Founder and CEO Nir Altschuler tells ISRAEL 21c that this is a breakthrough in the field — the “Holy Grail” in orthopedics — because other experimental treatments generate only “hyaline-like” cartilage, which is actually a non-lasting fibrous tissue rather than the real deal.

“Our clinical results, to date, confirm rapid cartilage and bone formation, as clearly visible on MRIs and X-rays,” says Altschuler. “Patients are reporting significant improvement in pain level and return to normal function, including sports.”

The implant has earned the European Union’s CE Mark of approval, and the company is currently running post-marketing clinical studies at leading centers in Europe.

Cartilage can’t self-repair

There are approximately 1.2 million cartilage repair procedures performed annually worldwide, and these surgeries mainly aim for pain relief since it hasn’t been possible until now to regenerate true hyaline cartilage.

Altschuler says Agili-C has the potential to heal the problem at an early stage and halt further joint degeneration, and therefore might have the potential to prevent the need for more radical procedures, such as knee replacement, down the road.

The implant provides a scaffold that enables stem cells to climb up from the bone marrow, form vessels within the scaffold and regenerate tissue, Altschuler explains.

Within a few months, the top layer becomes cartilage while the bottom layer becomes bone – each identical to the body’s own tissues. The regenerated cells gradually dissolve the implanted scaffold and the joints are nearly as good as normal.

The first patient to receive Agili-C was a 47-year-old Slovenian man, a former athlete whose knee cartilage was damaged due to a volleyball injury six years before the June 2011 surgery. Unable to enjoy sports, he suffered on and off from knee swelling and pain.

Six months after receiving the Agili-C implant, the patient was on the ski slopes. A year from his surgery, he completed a 180K cycling marathon, according to company officials.

“The X-ray and MRI images are promising,” says Altschuler. “At six months you can see signs of cartilage formation and at a year it is nearly fully regenerated. The newly formed cartilage is hyaline cartilage, the body’s native cartilage, distinguished by its specific type of collagen.”

Altschuler founded CartiHeal in 2009 as a portfolio company of Peregrine Ventures’ Incentive Technological Incubator. Today, CartiHeal is backed by a recent financing round of up to $10 million from Accelmed, Access Medical Ventures and Elron."
 

Rahman Qureshi (76)
Wednesday January 16, 2013, 8:14 pm
Cool!
 

jo M. (3)
Wednesday January 16, 2013, 8:35 pm
Wow, I could really use this!
 

Patricia Martin (19)
Wednesday January 16, 2013, 9:18 pm
Me, too!
 

Carol Dreeszen (364)
Wednesday January 16, 2013, 9:24 pm
Another contribution from Israel!! Let's just hope that none of those complainers of Israel EVER decide they REALLY need this to be done! Time then to say "hit the road jack!"
 

Tommy S. (11)
Thursday January 17, 2013, 12:09 am
Genesis 12:2/3
And I will make of you a great nation, and I will bless you, and make your name great; and you shall be a blessing:And I will bless them that bless you, and curse him that curses you: and in you shall all families of the earth be blessed.
TGFI
 

Stan B. (124)
Thursday January 17, 2013, 12:33 am
Israel punches well above its weight in so many areas of human endeavor. Just imagine what this tiny country could achieve if it didn't have to spend so much of its GDP protecting itself against insane neighbours!!!
Thanks Beth.
 

Rob and Jay B. (122)
Thursday January 17, 2013, 5:38 am
This is wonderful news! We must all know people with joint deterioration and pain and those who have have hip and knee replacements, which don't seem to ever really work very well. This wonder should end that more invasive surgery forever.

There's a reason that Jews have earned 185 Nobel Prizes, mostly for medicine and science, and the most for any single group.

Great news! Thanks for posting this since it is something one of us is facing right now, and maybe this will stave off the dreaded surgery.
 

Carola May (20)
Thursday January 17, 2013, 5:41 am
Excellent! Thank you for sharing this good news!

Well, here's just one more thing for the Jew-hating anti-Israel bigots to 'boycott' Israel for :) If they boycotted Israel for every thing that it has produced for the benefit of all human kind, they would have to give up a lot. Well, let them.
 

Beth S. (323)
Thursday January 17, 2013, 7:29 am
I sure wish I had access to this a couple of years ago!
 

Donnaa D. (13)
Thursday January 17, 2013, 7:49 am
i need this badly brilliant
 

Linda B. (10)
Thursday January 17, 2013, 7:55 am
This is wonderful news!
 

paul m. (93)
Thursday January 17, 2013, 7:59 am

Nice one...
 

paul m. (93)
Thursday January 17, 2013, 8:02 am



Nice one...
 

Jane K. (10)
Thursday January 17, 2013, 9:25 am
Yes, wonderful news. Many of us would thankful .
 

Christeen Anderson (469)
Thursday January 17, 2013, 10:56 am
Thank you for this informative and interesting article.
 

Suheyla C. (229)
Thursday January 17, 2013, 11:10 am
thank you Beth
Wonderful news
noted
 

Allan Yorkowitz (453)
Thursday January 17, 2013, 2:18 pm
It's truly amazing the medical advances that are generated out of this small nation.
 

Nelson Baker (0)
Thursday January 17, 2013, 3:24 pm
Thank you for the article.
 

Alexander Werner (53)
Thursday January 17, 2013, 3:25 pm
It is truly amazing, that so many nations will use this Israeli invention to heal their sick, yet they voted in UN to give Israeli land to Arabs for 23rd state.

I am not aware of any sizable contribution of Arab states into the World medicine or economy. Then why are we rewarding noisy beggars, just because they are many and have oil?
 

linda g. (3)
Thursday January 17, 2013, 6:14 pm
Great news for persons having a long-term disability or have experiened a burstis. Have cerebral palsy; fell and landed on my knees alot. Still o.k. but info good for future reference.
 

Hilary S. (45)
Thursday January 17, 2013, 6:32 pm
i love the way israel creates problems for the BDS crowd!
may those who would boycott israel hobble around on their dodgy knees, rather than betray their foolish racist principles.
 

Mitchell D. (130)
Thursday January 17, 2013, 6:37 pm
I may need to go there, someday, one never knows, do one?
 

Kara C. (15)
Thursday January 17, 2013, 9:27 pm
AWESOME! If they need a dog to test on I have the perfect patient right here, hopefully a cure for arthritis is found soon its such a horrible condition.
 

pam w. (191)
Thursday January 17, 2013, 10:08 pm
As someone who's had TWO artificial knees installed due to lack of cartilage....this sounds like a magic bullet. Some of this technology exists today in the States but, if the Israelis have found a better way to do it and eliminate joint problems....HOORAY FOR THEM!

I love the fact that they're trying.....while their neighbors are busy plotting murder, torture, oppression and destruction....the Israelis are trying to help humanity.
 

june t. (65)
Friday January 18, 2013, 12:23 am
thanks for the article
 

Natalie S. (9)
Friday January 18, 2013, 4:56 am
I do hope these researchers continue their studies to ensure the safety of the procedure and, perhaps, bring down the cost of the intervention.
 

Donna Hamilton (136)
Friday January 18, 2013, 5:50 am
Wonderful news; I know so many people who could benefit from this. Thanks for the article, Beth.
 

Brad Kraus (6)
Friday January 18, 2013, 9:33 am
Great post. I will have to forward to my sister. Of course it probably wouldn't be covered by Medicare if approved for use in the US.
 

Les L. (16)
Friday January 18, 2013, 1:27 pm
Great post and thanks!
 

Patricia H. (468)
Friday January 18, 2013, 2:55 pm
thanks for sharing
 

Lynne Buckley (0)
Friday January 18, 2013, 4:26 pm
Very interesting
 

Klaus Peters (11)
Saturday January 19, 2013, 2:47 am
Thanks Beth, and well done Israel. I hope my wife can benefit from this discovery. Maybe in the near future this proceedure will be available in Australia.
 

John S. (300)
Saturday January 19, 2013, 6:54 am
Thanks, hopefully it will help those that suffer.
 
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