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Promising New Drug Target Discovered for Treatment and Prevention of Heart Failure

Health & Wellness  (tags: health, drugs, disease, heart, prevention, research, study, treatment, protection, science, medicine )

- 2092 days ago -
A promising new drug target for the treatment and prevention of heart failure has been discovered by researchers at Mount Sinai School of Medicine in New York, NY, US.

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Dee C (229)
Sunday August 26, 2012, 8:55 am
The study was presented at the ESC Congress 2012 by principal investigator Professor Roger J. Hajjar, MD.

According to the US Centers for Disease Control and Prevention, about 5.8 million Americans suffer from heart failure and 670,000 new cases are diagnosed each year. One in five people with heart failure die within one year of diagnosis. Heart failure is most often treated with aggressive medical and device therapy, but has no cure. The most common symptoms of heart failure are shortness of breath, feeling tired, and swelling in the ankles, feet, legs, and sometimes the abdomen.

In this study presented at the ESC Congress 2012, researchers identified a new drug target that may treat and/or prevent heart failure. The team evaluated failing human and pig hearts and discovered that SUMO1 (small ubiquitin-like modifier), a small protein that regulates the activity of key transporter genes, was decreased in failing hearts. When the researchers injected SUMO1 into these hearts via gene therapy, cardiac function was significantly improved.

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Past Member (0)
Tuesday August 28, 2012, 7:38 pm
I don't see the greedy pharmaceutical companies rushing to get this on the shelves, considering it will cost them hundreds of billions in the sales of their current "keep them barely alive and dependent" drugs.

Kathleen R (138)
Wednesday August 29, 2012, 8:39 am
noted & read

Patricia H. (440)
Wednesday August 29, 2012, 9:28 am
noted, thanks for sharing

Robert O (12)
Wednesday August 29, 2012, 12:16 pm

Marianna molnar woods (9)
Thursday August 30, 2012, 1:36 am

Debbie Butz (3)
Thursday August 30, 2012, 12:45 pm

marie C (163)
Thursday August 30, 2012, 2:02 pm
Noted thanks Dee

Tom C Sullivan (98)
Thursday August 30, 2012, 7:53 pm
Right on,

Seda A (4)
Sunday September 2, 2012, 3:26 am
noted, thanks
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