Do Soybeans Really Offer HIV Resistance?

Could the humble soybean really provide us with a new and more effective HIV inhibitor that comes without the drug resistance problems found in current therapies?

Researchers at the George Mason-based National Center for Biodefense and Infectious Diseases and the Department of Molecular and Microbiologyhave found that there is potential if further tests on genistein, a compound derived from soybeans and other plants, continue to show positive results.

“Instead of directly acting on the virus, genistein interferes with the cellular processes that are necessary for the virus to infect cells,”said lead researcher Yuntao Wu. “Thus, it makes the virus more difficult to become resistant to the drug. Our study is currently in its early stage. If clinically proven effective, genistein may be used as a complement treatment for HIV infection.”

HIV hijacks the surface sensors of our cells in order to replicate itself. Genistein, the compound derived from soybeans, is known as a “tyrosine kinase inhibitor.” That means it can block communication from a cell’s surface sensors to a cell’s interior. As such, it would retard HIV infiltration and proliferation in the body, effectively hampering the virus from spreading.

As mentioned above, genistein may have other benefits too. Due to the fact that it is a plant-based compound, it has the potential to offer a HIV treatment that could sidestep what is known as drug toxicity.

Many HIV patients are forced to take a combination of several drugs in order to stop HIV advancing in their bodies. As a result, HIV sufferers may become ill as a result of their daily regimen of drugs.

In addition to this, there is also the fact that HIV can mutate and become resistant to the drugs a sufferer is currently using.Genistein potentially would not be subject to such constraints or offer the toxicity side effects of other drugs.

Now, this isn’t the first time that the soybean compound has been eyed as a potential contender for a new wave of HIV treatments. Researchers have known of soybean’s potential HIV inhibiting properties sinceat least 2008, and a2011 Chinese study investigated the potential of the mini-black soybean as a protease inhibitor that, again, could slow HIV spread in the body.

Soybeans have also been found to contain the potential for anti-cancer drugs, thoughextracting the precise compounds for refinement has been difficult.

Sadly though, it seems unlikely that a daily diet of genistein-rich food such as soybeans could, on its own, provide sufficient concentrations of the compound to offer HIV resistance.

“Although genistein is rich in several plants such as soybeans, it is still uncertain whether the amount of genistein we consume from eating soy is sufficient to inhibit HIV,” Wu is quoted as saying.

Wu and team are now attempting to research exactly the amounts that would be needed to offer health benefits and whether refining a drug treatment based on the compound will be viable. Alternatively, it may be that soybeans and other genistein-rich plants could be engineered to offer greater concentrations of genistein but, of course, this comes with its own set of limiting factors, not least of which is the potential wider environmental impact.

With an eye to the viability of treatment, genistein would never be a stand-alone HIV inhibitor, and certainly not an HIV cure.

What it does have the potential to be, however, is an inexpensive HIV inhibitor that might come with fewer medical issues than the current, harsh variety of drug treatments.

Image credit: Thinkstock.

84 comments

Past Member
Past Member 5 hours ago

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Rose M.
Rose M.1 days ago

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John A.
John A.2 days ago

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John A.
John A.2 days ago

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John A.
John A.2 days ago

​

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John A.
John A.2 days ago

​

Hi Everyone here in this forum, I am here to share with you all about how Dr JOHN who was able to cure me from HIV with his Herbal Medicine, Been with HIV is something someone is never comfortable with, I was tested and confirmed HIV positive few years ago and i was taking medical treatment from my Doctor, some time back now while i was on the Internet i saw different amazing testimonies concerning Dr JOHN on how he has healed people from various sickness, someone also testified about how he was cured from Diabetics with the Help of Dr JOHN Herbal Herbs Medicine, they gave his personal information and advice anyone to contact him that he also help in all kinds of STD AND STI Diseases if you need his help, i took the email address of Dr JOHN and i sent him a message regarding my Problem and how he could possibly help me out, He responded to me and told me to have the faith and believe in God, Dr JOHN told me that he was going to prepare some Herbs for me which i am to take for some time as my medication, he told me the procedures and i agreed to it, after some days of communicating with Dr JOHN he actually sent me a package and he gave me the tracking number to my package, he gave me prescription on how i am to use the Medicine,after taking Dr JOHN Herbal Medicine i went back to my Doctor for another test and to my greatest surprise my result turned out Negative, and i still did not believed it i went to other hospitals for an

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John A.
John A.2 days ago

​

Hi Everyone here in this forum, I am here to share with you all about how Dr JOHN who was able to cure me from HIV with his Herbal Medicine, Been with HIV is something someone is never comfortable with, I was tested and confirmed HIV positive few years ago and i was taking medical treatment from my Doctor, some time back now while i was on the Internet i saw different amazing testimonies concerning Dr JOHN on how he has healed people from various sickness, someone also testified about how he was cured from Diabetics with the Help of Dr JOHN Herbal Herbs Medicine, they gave his personal information and advice anyone to contact him that he also help in all kinds of STD AND STI Diseases if you need his help, i took the email address of Dr JOHN and i sent him a message regarding my Problem and how he could possibly help me out, He responded to me and told me to have the faith and believe in God, Dr JOHN told me that he was going to prepare some Herbs for me which i am to take for some time as my medication, he told me the procedures and i agreed to it, after some days of communicating with Dr JOHN he actually sent me a package and he gave me the tracking number to my package, he gave me prescription on how i am to use the Medicine,after taking Dr JOHN Herbal Medicine i went back to my Doctor for another test and to my greatest surprise my result turned out Negative, and i still did not believed it i went to other hospitals for an

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Penny K
Past Member 14 days ago

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Penny K
Past Member 14 days ago

Hello all viewer online HIV has cure but doctor said Hiv/Aids has no cure until i met Dr Zuku who help me in my life. I was infected with HIV/AIDS in 2006, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution, so that my body can be okay. until this faithful day as i was browsing the net I saw a testimony on how Dr.Zuku helped people in curing HIV Disease, quickly I copied his Email which is drzukuspelltemple@gmail.com so i contacted him for solution for my HIV, so Dr.Zuku told me that his going to prepare herbal medicine for my health, then he prepared the medicine and luckily after two week my herpes was be cured. Dr Zuku is well recognize as one of the best herbalist doctor in Africa, you don't have to be sad anymore or share your tears anymore on this disease when the cure have already be found by Dr.Zuku herbal medicine, he so cure HERPES,CANCER, ALS,HEPATITIS B, DIABETIC ,or his Mobile number: +16177296273 or his Blogs https://drzukuspelltemple.blogspot.co.ke/ his website https://drzukuspelltemplewhereallkindsofproblemisbesolve.wordpress.com/contact/

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Angela Grier G
Past Member about a month ago

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