Ridding the Body of ‘Retired’ Cells Could Reverse the Ageing Process

To live†a long and healthy life, we know†long-term†lifestyle habits (such as diet, exercise, sleep, etc.) are important. But what if you had the opportunity to enhance your anti-aging efforts with a “rejuvenation injection” every few years or so?

Believe it or not, rejuvenation injections could be a serious†anti-aging trend of the future. A study conducted by researchers at†the Erasmus University Medical Center in the Netherlands found that by eliminating “retired” senescent cells in older mice, biological†deterioration slowed down and several functions were restored to†younger, healthier states.

Cells that accumulate†unrepairable DNA damage from†stress†or†aging either tend to give rise to cancer, self-destruct, or enter a partially dormant state known as senescence. These senescent cells can cause†inflammation and enzymes that are harmful to connective tissues, which can contribute†to health conditions like heart disease, arthritis, and diabetes.

In this study, the researchers gave a substance designed to destroy senescent cells to two groups of mice. One group of mice had†aged naturally while the other†had been genetically modified to age at a faster rate.

After receiving the substance three times a week over a long-term period of 10 months, the researchers not only observed improved kidney function in the mice after about a month of treatment, but also significant physical transformations soon after the substance was being regularly administered.†Some of the mice that were part of the rapid aging group experienced†age-related fur loss, but†showed signs of fur regrowth within†just 10 days of receiving the substance.

After†three weeks, the rapid aging mice started showing†big improvements in their activity levels, demonstrating their ability to run twice the distance of comparably old mice that didn’t receive the substance. The researchers are now looking at whether the substance might help extend the lifespans of the mice. If it does,†the researchers will†move on to begin carefully studying how these effects might also take place in humans.

Related research from last year showed that the elimination of senescent cells via genetic modification in mice helped them live 20 percent longer on average. This newer study, however, is the first of its kind to show not only that†delayed†ageing†may be possible with rejuvenation injections, but also that reversing the natural process of ageing is†possible as well.

There are, however, potential consequences of removing senescent cells that will govern how†future research might be carried out ó especially in future studies with†humans. For instance, it’s researchers don’t know what might happen after they†take†out senescent cells beyond a certain threshold.

Although the study presents†landmark advancements in anti-ageing, it could be a long while before we see any sort of rejuvenation injection available to people. For now, we’ll have to stick to encouraging healthy ageing the†old fashioned way ó by adopting healthier lifestyle habits.

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Photo Credit: Thinkstock


Jerome S
Jerome S7 months ago


Jim V
Jim V7 months ago

thanks for sharing.

Sarah Hill
Sarah Hill7 months ago


Carl R
Carl R8 months ago


Elaine W
Elaine W8 months ago


heather g
heather g9 months ago

Poor mice...

Dorre R
Dorre R9 months ago

Good explanation - that the treatment removed cells with unrepairable DNA damage before they could cause cancer or inflammation. Makes sense. Thanks!

Leanne K
Leanne K9 months ago

Grow old everyone and let the mice go!

Leanne K
Leanne K9 months ago

Within the first paragraph animal testing is mentioned. Thats where i stopped. Not at all interested in ANYTHING to do with tests and experiments on animals , including written articles!

Winn A
Winn A9 months ago