The Scary Truth About Depression and Dementia

Memory trouble, excessive sleeping, decreased interest in hobbies and activities, social withdrawal—all of these are symptoms often exhibited by a person who is suffering from depression.

They also happen to be hallmark signs of many dementias, including the two most common forms: Alzheimer’s disease and vascular dementia.

The undeniable connection between depression and dementia has ignited a firestorm of research in recent years. Much of the scientific debate centers on a quintessential chicken and egg dilemma—which comes first: depression or dementia?

Can being diagnosed with dementia cause someone to become depressed, or is depression a harbinger of cognitive impairment to come?

Examining the relationship between dementia and depression

Several new studies aimed at illuminating the relationship between these two cognitive conditions has shed some interesting light on how depression might affect a person’s risk for exhibiting signs of dementia later on in life.

A bout of depression may potentially triple a person’s risk for developing dementia, according to research recently published in the Archives of General Psychiatry.

Scientists from the University of California, San Francisco, found a significant link between depression and the two most common forms of dementia—Alzheimer’s disease and vascular dementia. The timing of the onset of depression (mid-life versus late-in-life) appeared to have an impact on which type of dementia an individual was more likely to get.

An individual who struggled with depression in their 40s and 50s, was found to be three times more likely than a person without mid-life depression to develop dementia—specifically vascular dementia, which is caused by brain damage due to disrupted blood flow—in their later years.

If, however, an individual became clinically depressed in their 80s and beyond, they were twice as likely as their non-depressed peers to develop Alzheimer’s dementia.

A separate study, published in the British Journal of Psychiatry, showed similar results, with a slightly different slant.

In their investigation, University of Pittsburgh researchers concluded that late-life depression did indeed increase an individual’s risk for acquiring dementia. However it was vascular dementia—not Alzheimer’s—that appeared to be most prevalent in depressed older adults.

Causes both biological and behavioral

When asked to explain the mechanisms behind the depression-dementia link, experts extoll a variety of theories.

According to Kenneth Freundlich, Ph.D., a clinical neuropsychologist with the Morris Psychological Group, there are currently several different biological factors that may help explain the relationship between depression and dementia:

  • Confusing cortisol: Depressed individuals tend to produce higher amounts of the hormone cortisol, which can impair the areas of the brain that are responsible for short-term memory and learning.
  • Disorienting inflammation: Depression can also cause blood vessel-damaging inflammation to occur in the brain.
  • Stress-induced damage: The hippocampus, the part of the brain responsible for turning information into memory, can be harmed when exposed to extended periods of stress.

However, he cautions that no one model has been identified as the explanation for the depression-dementia connection.

“Despite a variety of theories, the depression-dementia link is one that is not fully understood,” he says, “People who are experiencing the early stages of dementia frequently become depressed and people who are depressed have an increased risk for developing dementia.”

There are also certain behavioral elements which may play a role, according to Robin Dessel, Director of Memory Care at the Hebrew Home at Riverdale, Dessel says, “Depression and dementia mirror each other in a catalogue of symptoms and triggers. There is a very real and integral connection between the health and well-being of brain and body, mind and spirit.”

For example, one of the primary symptoms of depression is an unwillingness to engage in regular activities and socialization opportunities, which may lead to what Dessel refers to as an, “inactive brain and a depressed lifestyle.”

This lack of action can enhance an individual’s susceptibility to showing signs of dementia, especially when compounded by certain genetic, physiological and environmental factors that have been shown to contribute to cognitive impairment.

How to beat back depression, no matter what your age

If you’re concerned that you (or someone you love) may have depression, Dessel says the first step is to seek a formal diagnosis from a qualified medical professional.

After an official diagnosis has been made and a treatment plan—involving talk therapy, medications or a combination of both—has been drawn up, Dessel suggests also turning to holistic therapies (i.e. mediation, yoga, breathing exercises, etc.) to, “foster health and harmony,” in a person with depression.

She also offers a few additional drug-free tips to combat the disorder:

  • Approach the healing process the right way: Depending on a person’s individual situation, medications to manage their depression symptoms may or may not be necessary. Either way, Dessel suggests emphasizing activities that, “re-ignite the human spirit,” in a person with depression. She says that she has seen first-hand how interventions such as visualization, yoga and deep breathing can help people combat the disorder.
  • Infuse life with fulfilling activities: Ask yourself: What used to bring happiness and fulfillment to my (or my loved one’s) life? Attempt to incorporate these passions into a regular routine.
  • Get out of the house: Dessel also recommends “fresh air therapy” as a wonderful way to help an individual with depression re-connect with the invigorating energy of the living world.

Decoding the Dementia, Depression Link originally appeared on

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By Anne-Marie Botek, Editor


Wisteria K.
Past Member 5 years ago

So we can try to prevent dementia by treating persons for depressions .
I wonder if treatment with antidepressants is a treatment of depression that reduces the chance of dementia later on ?
Antidepressants is also said to increase the risk for dementia and Alzheimer later on.

Michael S.
Michael S5 years ago

Those symptoms are also symptoms of various drug addictions and/or side effects to various prescription drugs.

Cynthia B.
cynthia l5 years ago

Talk about depressing according to this very few people are safe. hmm so vascular dementia is caused by brain damage which is what like head injuries ? How about alcoholism?
My friend's father had Alzheimer's due to being a sever alcoholic and the brain cells he killed. He did not know her which was heartbreaking.
However any night of excessive drink kills brain cells.
I have suffered with bouts of depression since age 18 and worsened with post partum depression that was undiagnosed for to long. Back then you were just crazy. I read everything I can get my hands on and am more interested in natural ways to help. I don't want to do chemical meds The bottom line is therapy and rooting out the issues thx

Teresa Wlosowicz
Teresa W5 years ago

I suffer from excessive sleeping. I hope it's only depression...

Sandra Walker
Sandra K. Walker6 years ago

I have been on medication for depression for at least 20 years.My doctor at that time put me on the medication.
After reading some of the off sets can bring from depression scare me.Never knew that Alzheimer Could maybe effect my life.
Great article to read,even if I don't like what I read.

JL A6 years ago

good to know

Elena T.
Elena Poensgen6 years ago

Thank you :)

Terry V.
Terry V6 years ago


Eternal Gardener
Eternal G6 years ago

Eat healthy and keep moving.

Lindsay P.
Lindsay Partin6 years ago

What about those of us who have been diagnosed with depression in their late 20's? I haven't been on meds for at least a year now and while I sometimes feel like it's coming on, I'm normally able to keep it at bay. Getting back into a social scene with wonderful, uplifting friends, getting back with my church family and meeting a wonderful man who I am now engaged to I know has really helped my depression. I was diagnosed several months after my mother died. My father died 11 months before my mother and I took care of both of them. I knew that nothing I could do was really going to help them. They were still dying, but I was in denial about it. I was really only keeping them as comfortable as I could. Summer can be a bad time for me because both of my parents died in the summertime, but then if I can get to the beach, I go. It's my favorite way to relax and destress.