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Genetic Pathways for Brain & Pancreatic Cancer Mapped

Science & Tech  (tags: cancer, genetic research, pancreatic cancer, brain tumors, tumors, genes, medical research )

- 3970 days ago -
The most comprehensive study ever conducted on human tumors revealed 12 core pathways in pancreatic cancer & 3 core pathways in brain cancer that genes use to mutate into deadly tumors. But they also found that no human tumors are identical.


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RC deWinter (418)
Friday September 5, 2008, 6:10 pm
The people involved in this research discovered that cancer's genetic development is totally chaotic. Although pancreatic tumors typically had 63 genetic mutations and typical brain tumors had 60, each tumor differed from every other.

But being able to target the specific pathways, instead of a single gene, that helps these two types of cancer form can potentially lead to treatments that can be delivered to the route the genes use and not just to a single gene. It won't be easy to block off the pathways with drugs, but research teams have already begun studying how to block enzymatic pathways that mutating genes use. Also, it may be possible to trap mutant DNA in the bloodstream before tumors begin to spread. This is a giant step forward!

Joycey B (750)
Friday September 5, 2008, 6:10 pm
Thanks for this information Cate.

James M (190)
Friday September 5, 2008, 7:20 pm
I did research on plant galls when I was in college. They're a form of plant "cancer" but they are often highly specialized and appear to be under the direction of the developing larva (often wasps, but can also be caused by small flies.) In essence, the insect creates an environment that shelters and feeds it's young. They are the original genetic engineers. I thought then, and I still believe strongly that there are answers there to the control of cancer. Thanks for the info Cate.

Friday September 5, 2008, 8:22 pm

. (0)
Friday September 5, 2008, 8:47 pm
noted thank you

Past Member (0)
Friday September 5, 2008, 9:29 pm
Very Good information.

. (0)
Friday September 5, 2008, 9:54 pm
Thanks Cate for the good information.

Marian E (152)
Saturday September 6, 2008, 12:32 am

That last paragraph held the most interest for me. That could be, not just a life saver, but
a brain saver. (And if you've known someone who survived brain cancer, you know that the brain damage can be horrific.)

Thank you Cate. Good article!!!

Mary H (47)
Saturday September 6, 2008, 1:09 am
TY Cate

Saturday September 6, 2008, 2:10 am
Cate I was amazed doing some reading that they have found pieces and old genetic material of viruses in humans from the past. So we have the ability without drugs to overcome viruses ,some that cause cancer if not all cnacers. They mystery is how did the human body accomplish this in the past since it has happened. What force controls the unleashing of our bodies abilities to heal its'self ????chris

Saturday September 6, 2008, 2:14 am
James very well put I also think you are right as I stated above the secret is the knowledge to unlock the bodies capacity to fight the cancer. Is it spiritual in food or even other animals involved? I am very amazed about the insect and plant work you did. I also was a enviornmental bio student and we did detailed damage to certain plants by insects and the outcome fascinating. But man has to stop poisioning the host our EARTH! Chris

ROBIN M (312)
Saturday September 6, 2008, 4:49 am
I remember the day they told me my mom had pancreatic cancer they said she would not get better but could they open her up to see what her pancreas looked like while she was still alive and that is how they put it we said no way. We were horrified they would even suggest such a thing they said if we can't opperate then there is no need for her to be here that she had to leave. They at least called hospice first mind you I had no idea what the pancreas was I was too young to even know what hospice was I kept wondering who are these people what are they talking to us about. I found out 3 weeks later she died from the day we found out she had it till the day she passed was 3 weeks I never seen any thing go so quick and so hard on someone in my whole life and hope to never see it again she went from 200 pounds in 3 weeks down to 85 and that was the end. It ended on Thanksgiving morning at 12 midnight.

Dolores H (2)
Saturday September 6, 2008, 5:59 am
This study in indeed encouraging.

Stephen Hannon (203)
Saturday September 6, 2008, 10:01 am
Noted, thanks Cate.
I had a cancerous Basal Cell removed from my face a couple of years ago that came back positive for skin cancer from the Pathololgy Department at the hospital. I was referred to a Plastic Surgeon to have the Cell removed. It left a scar that looks like a football on my face just under my right eye. It is barely noticable, and you'd miss it if you weren't looking for it. Gee, I don't even notice that often when looking in the mirror, but then my reflection ran away when I looked in...Now there's just an empty space where a face should be.....

Susan L (118)
Saturday September 6, 2008, 10:12 am
Noted. Very informative. Thanks, Cate.

Past Member (0)
Saturday September 6, 2008, 11:15 am
Years ago the very word cancer would literally scar me to death. But that was a very long time ago. Now reading of it & seeing/hearing the word does not scar me so much.

This a very informative article......


Terrie Williams (798)
Saturday September 6, 2008, 11:31 am
Thanks for bringing it to us, Cate!

Estella Ameigh (22)
Saturday September 6, 2008, 7:44 pm
Thanks Cate. This is wonderful news.

Gail L (30)
Sunday September 7, 2008, 5:40 pm
Thanks for the info.

Louise L (48)
Monday September 8, 2008, 2:57 pm
Our bodies are amazing, aren't they? So complicated, with bits and pieces of leftovers from diseases that attacked ancestors back many generations. We should be glad for the protection: it's going to be why a few of us survive the bird flu. I read the same thing about the plagues that used to strike entire populations, that it was their genetic memory that made sure some people survived. It's exciting to be on the cusp of medical breakthroughs such as this!!! Thanks, Cate. Robin, we are so sorry for the loss of your mother; so tragic.

Denice G (45)
Tuesday September 9, 2008, 4:36 pm
This is really interesting. Thanks again Cate
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